ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Chemistry
Collection
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 6 (1994), S. 161-164 
    ISSN: 0899-0042
    Keywords: homochiral amines ; N,N-ditosylimides ; azides ; inversion of configuration ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: More effective use of optical resolution processes can be obtained by increasing the overall yields after development of methods for inversion of the chiral centre of the unwanted isomer. The configuration of some optically active amines can be inverted in a three-step synthesis via the N,N-ditosylimides and a subsequent nucleophilic substitution by the azide ion. The azide product is reduced by hydrogenolysis. Low stereoselectivity caused by racemization to some extent was at first observed for the inversion of the benzylic substrate, (S)-α-methylbenzylamine (5a). However, modified reaction conditions allowed increased stereoselectivity, a more rapid and almost complete inversion of this substate as well. © 1994 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...