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Pharmacokinetics of paroxetine in patients with cirrhosis (1991)

Dalhoff, K. ; Almdal, T. P. ; Bjerrum, K. ; [et al.]

Springer

European journal of clinical pharmacology 41 (1991), S. 351-354

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ISSN: 1432-1041

Keywords: Paroxetine ; Cirrhosis ; pharmacokinetics ; multiple-dose study ; adverse effects

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary In a 14-day multiple-dose study the pharmacokinetics of paroxetine was investigated in 12 patients with alcoholic cirrhosis and in 6 subjects without liver disease. The dose of 20–30 mg paroxetine daily was adjusted to the reduction in liver function, as assessed by the galactose elimination capacity. Accordingly, all but two of the cirrhotic patients received 20 mg, while all six control subjects received 30 mg. Dose-corrected, trough drug concentration at steady state (CSS min) and dose-corrected AUC24h were significantly higher in the patients with liver diseases than in the control subjects [3.4 vs 1.5 ng · ml−1 per mg paroxetine and 89 vs 43 h (ng) · ml−1 per mg paroxetine]. The elimination t1/2 was prolonged [83 vs 36 h], but the difference was not statistically significant, and the cirrhotic patients were still able to clear almost all the paroxetine by metabolism. All but two patients with cirrhosis experienced nausea during the first two or three days after the first dose, while none of the controls had this symptom. The study showed slower elimination of paroxetine and consequently higher plasma levels in patients with cirrhosis, suggesting that in the latter the dose of paroxetine should be in the lower end of the therapeutic range.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00314966

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Geometry effects and high speed tensile behavior in styrene polyblend systems (1964)

Lund, J. Kenneth

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 8 (1964), S. 73-87

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: Critical specimen geometry parameters are varied to determine their effect on tensile behavior as a function of rate of testing. Their influence on elongation and energy absorption is pronounced, particularly at low values of specimen cross sectional area and thickness. These effects are attributed to surface imperfections resulting from specimen preparation, and to changes occurring in the combined stress pattern in the specimen. High speed photography and microscope analysis techniques have been developed to determine strain, strain distribution, and strain rate in the specimen gage section during deformation. Elongation measured outside the gage section can be a significant portion of overall specimen deformation; actual strain rate is a fraction of that obtained by assuming all deformation takes place in the gage section. Experimentation is statistically designed and the data statistically analyzed by sequential factorial analysis. Tensile stress response surfaces are accurately predicted by this technique.

Additional Material: 14 Ill.