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  • 1
    Electronic Resource
    Electronic Resource
    Kinetik der Hydrid-Übertragungen von CH-, SiH-, GeH- und SnH-Gruppen auf Carbenium-IonenDiese Arbeit wurde von der Deutschen Forschungsgemeinschaft und dem Fonds der Chemischen Industrie gefördert.Professor George A. Olah zum 65. Geburtstag gewidmet (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 104 (1992), S. 1103-1105 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19921040843
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  • 2
    Electronic Resource
    Electronic Resource
    γ-Immobilized SE-30 on chromsorb supports for use in packed-column gas chromatography (1989)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 12 (1989), S. 500-502 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography ; Non-polar stationary phase ; Immobilization ; γ Irradiation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240120724
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  • 3
    Electronic Resource
    Electronic Resource
    Solid-phase dendrimer synthesis (1998)
    New York : Wiley-Blackwell
    Biopolymers 47 (1998), S. 381-396 
    Details
    ISSN: 0006-3525
    Keywords: solid-phase synthesis ; dendrimer ; hyperbranched polymers ; polyamidoamine ; bead loading amplification ; multiple antigen peptide system ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dendrimers are highly ordered, hyperbranched polymers with potential for a whole range of chemical applications. Solution-phase synthesis of dendrimers is often challenging, requiring long reaction times and nontrivial purification; solid-phase methodology, on the other hand, enables reactions to be driven to completion by using a large excess of reagents with trivial purification. In this paper we show that polyamidoamine dendrimers may be synthesized conveniently and efficiently on a solid support, and that these molecules are of good homogeneity as characterized by 1H- and 13C-nmr and electrospray mass spectrometry. These solid-phase dendrimers were used as a bead loading amplification tool in the synthesis of a hexapeptide library (Xaa-Gly-Gly-Phe-Leu-Lys) to allow single bead analysis as well as allowing the efficient synthesis of two dendrimer conjugates (Leu-enkephalin-Lys and Chlorambucil). This demonstrated that peptides and small drug molecules can be grown directly onto the dendrimer or onto a linker attached to the dendrimer periphery, enhancing general dendrimer utility. © 1999 John Wiley & Sons, Inc. Biopoly 47: 381-396, 1998
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New Approach to β-Lactam-Fused Enediynes (“Lactenediynes”) by Stereoselective Pinacol Coupling (2000)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 2000 (2000), S. 939-946 
    Details
    ISSN: 1434-193X
    Keywords: Enediynes ; Vanadium ; C-C coupling ; Macrocycles ; Lactams ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A short synthesis of unfunctionalized lactenediyne 3 by closure of the ten-membered ring at the double bond site is reported. After failure of the known methodologies, this closure was eventually successfully achieved thanks to a highly stereoselective, vanadium(II)-mediated pinacol coupling of bis(alk-2-ynal) 7.Supporting information for this article is available on the WWW under //http://www.wiley-vch.de/contents/jc_2046/2000/99471_s.pdf or from the author.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetics of Hydride Transfers from CH, SiH, GeH, and SnH Groups to Carbenium IonsThis work work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie.Dedicated to Professor George A. Olah on the occasion of his 65th birthday (1992)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 31 (1992), S. 1046-1048 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.199210461
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  • 6
    Electronic Resource
    Electronic Resource
    Proton resonance spectra and substituent-induced chemical shifts of 3-halocamphors (1994)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 32 (1994), S. 503-508 
    Details
    ISSN: 0749-1581
    Keywords: 1H NMR ; 3-Halocamphors ; COSY-45 ; Molecular geometries ; Substituent-induced chemical shifts ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Complete signal assignments of high-field 1H NMR spectra for 3-halosubstituted camphors (endo and exo) are presented, allowing a refinement of a previous analysis for the chloro (endo and exo) and bromo (endo) derivatives. In addition, still unpublished data for the dichloro and exo-fluoro derivatives and for three new compounds (endo-fluoro, endo- and exo-iodo), in addition to a revised assignment of the camphor parent molecule, are reported. The precise substituent-induced chemical shifts (SCS) obtained for these difunctional systems are examined on the basis of well known transmission mechanisms aided by correlations with steric and electronic parameters, and taking into account SCS data from monohaloalkanes and the calculated molecular geometry data (using the AM1 method).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260320902
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  • 7
    Electronic Resource
    Electronic Resource
    Electronic interactions implied by the non-additivity of carbon-13 substituent parameters in 2-substituted cyclohexanones (1994)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 32 (1994), S. 205-209 
    Details
    ISSN: 0749-1581
    Keywords: NMR ; 13C NMR ; 17O NMR ; Cyclohexanones ; Orbital interactions ; Polar effects ; Substituent-induced shifts ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The carbon-13 chemical shifts were assigned for all ring positions in cyclohexanone and 4-tert-butylcyclohexanone with H, F, Cl, Br, I, MeO, MeS, MeSe, Me2N, Me or tert-butyl in the 2-position. The substituent-induced shifts were calculated by difference from unsubstituted cyclohexanone or 4-tert-butylcyclohexanone. Both stereoisomers (cis and trans) were available for the 4-tert-butylcyclohexanones in all but one case. Comparison of the substituent-induced shifts for the cis (equatorial 2-substituent) and trans (axial 2-substituent) isomers provides stereochemical insight into the interactions between the 2-substituent and the carbonyl group that bring about non-additivity of the substituent effects. In the 2-equatorial isomer, the dipole-dipole interaction between the functional groups causes non-additivities for the C-2 carbon that depend largely on the electronegativity of the 2-substituent. In the 2-axial isomer, hyperconjugation or other orbital interactions between the groups cause non-additivities for the C-2 carbon that depend largely on the polarizability in addition to the electronegativity of the 2-substituent.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260320403
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  • 8
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    Shared motor error for multiple eye movements (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-13
    Description: Most natural actions are accomplished with a seamless combination of individual movements. Such coordination poses a problem: How does the motor system orchestrate multiple movements to produce a single goal-directed action? The results from current experiments suggest one possible solution. Oculomotor neurons in the superior colliculus of a primate responded to mismatches between eye and target positions, even when the animal made two different types of eye movements. This neuronal activity therefore does not appear to convey a command for a specific type of eye movement but instead encodes an error signal that could be used by multiple movements. The use of shared inputs is one possible strategy for ensuring that different movements share a common goal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krauzlis, R J -- Basso, M A -- Wurtz, R H -- New York, N.Y. -- Science. 1997 Jun 13;276(5319):1693-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9180078" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eye Movements/*physiology ; Fixation, Ocular/physiology ; Macaca mulatta ; Motor Neurons/*physiology ; Pursuit, Smooth/physiology ; Saccades/physiology ; Superior Colliculi/cytology/*physiology ; Visual Pathways
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-03-26
    Description: Regulatory T cells (T(reg)) expressing the transcription factor Foxp3 control the autoreactive components of the immune system. The development of T(reg) cells is reciprocally related to that of pro-inflammatory T cells producing interleukin-17 (T(H)17). Although T(reg) cell dysfunction and/or T(H)17 cell dysregulation are thought to contribute to the development of autoimmune disorders, little is known about the physiological pathways that control the generation of these cell lineages. Here we report the identification of the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) as a regulator of T(reg) and T(H)17 cell differentiation in mice. AHR activation by its ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin induced functional T(reg) cells that suppressed experimental autoimmune encephalomyelitis. On the other hand, AHR activation by 6-formylindolo[3,2-b]carbazole interfered with T(reg) cell development, boosted T(H)17 cell differentiation and increased the severity of experimental autoimmune encephalomyelitis in mice. Thus, AHR regulates both T(reg) and T(H)17 cell differentiation in a ligand-specific fashion, constituting a unique target for therapeutic immunomodulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quintana, Francisco J -- Basso, Alexandre S -- Iglesias, Antonio H -- Korn, Thomas -- Farez, Mauricio F -- Bettelli, Estelle -- Caccamo, Mario -- Oukka, Mohamed -- Weiner, Howard L -- AI435801/AI/NIAID NIH HHS/ -- NS38037/NS/NINDS NIH HHS/ -- P01 NS038037/NS/NINDS NIH HHS/ -- R01 AI073542/AI/NIAID NIH HHS/ -- R01 AI073542-01/AI/NIAID NIH HHS/ -- R01 AI073542-02/AI/NIAID NIH HHS/ -- R01 NS059996/NS/NINDS NIH HHS/ -- R01AI073542-01/AI/NIAID NIH HHS/ -- England -- Nature. 2008 May 1;453(7191):65-71. doi: 10.1038/nature06880. Epub 2008 Mar 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18362915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbazoles/metabolism/pharmacology ; *Cell Differentiation ; Encephalomyelitis, Autoimmune, Experimental/chemically induced/immunology ; Forkhead Transcription Factors/genetics/metabolism ; Humans ; Indoles/metabolism/pharmacology ; Interleukin-17/*metabolism ; Ligands ; Mice ; Mice, Inbred C57BL ; Receptors, Aryl Hydrocarbon/genetics/*metabolism ; T-Lymphocytes, Helper-Inducer/*cytology/drug effects/*metabolism ; T-Lymphocytes, Regulatory/*cytology/drug effects/*metabolism ; Tetrachlorodibenzodioxin/metabolism/pharmacology ; Transforming Growth Factor beta1/immunology/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-23
    Description: Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally derived second-generation progeny, and identified a single quantitative trait locus (logarithm of odds = 31) on chromosome 6. A sulfotransferase was identified as the causative gene by using RNA interference knockdown and biochemical complementation assays, and we subsequently demonstrated independent origins of loss-of-function mutations in field-derived and laboratory-selected resistant parasites. These results demonstrate the utility of linkage mapping in a human helminth parasite, while crystallographic analyses of protein-drug interactions illuminate the mode of drug action and provide a framework for rational design of oxamniquine derivatives that kill both S. mansoni and S. haematobium, the two species responsible for 〉99% of schistosomiasis cases worldwide.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136436/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136436/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valentim, Claudia L L -- Cioli, Donato -- Chevalier, Frederic D -- Cao, Xiaohang -- Taylor, Alexander B -- Holloway, Stephen P -- Pica-Mattoccia, Livia -- Guidi, Alessandra -- Basso, Annalisa -- Tsai, Isheng J -- Berriman, Matthew -- Carvalho-Queiroz, Claudia -- Almeida, Marcio -- Aguilar, Hector -- Frantz, Doug E -- Hart, P John -- LoVerde, Philip T -- Anderson, Timothy J C -- 098051/Wellcome Trust/United Kingdom -- 5R21-AI072704/AI/NIAID NIH HHS/ -- 5R21-AI096277/AI/NIAID NIH HHS/ -- C06 RR013556/RR/NCRR NIH HHS/ -- HHSN272201000005I/PHS HHS/ -- R01 AI097576/AI/NIAID NIH HHS/ -- R01-AI097576/AI/NIAID NIH HHS/ -- R21 AI072704/AI/NIAID NIH HHS/ -- R21 AI096277/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Dec 13;342(6164):1385-9. doi: 10.1126/science.1243106. Epub 2013 Nov 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Biochemistry and Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24263136" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Drug Resistance/*genetics ; Gene Knockdown Techniques ; Genetic Linkage ; Helminth Proteins/*genetics ; Humans ; Molecular Sequence Data ; Mutation ; Oxamniquine/*pharmacology ; Phylogeny ; Protein Conformation ; Quantitative Trait Loci ; RNA Interference ; Schistosoma mansoni/*drug effects/*genetics ; Schistosomicides/*pharmacology ; Sulfotransferases/chemistry/classification/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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