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  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 737-742 
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthese von Pyrimidin-Analoga des Nucleosid-Antibiotikums AscamycinVier Analoga des Ascamycins 〈5′-O′-O-[N-(L-alanyl)sulfamoyl]-2-chloradenosin〉(1), bei welchen der 2-Chloradenosinrest durch Uridin, Thymidin, Cytidin und 2′-Deoxy-5-methylcytidin ersetzt wurde, sind durch selektive Aminoacylierung der 5′-O-Sulfamoyl-Derivate 2, 9, 14 und 21 des 2′,3′-Di-O-acetyluridins, 3′-O-Acetylthymidins, 2′,3′-O-Isopropylidencytidins, bzw. des 3′-O-Acetyl-2′-deoxy-5-methylcytidins mit Boc-L-Ala-OSu in DMF und in Anwesenheit von DBU, mit nachfolgender Abspaltung der Schutzgruppen, erhalten worden. Ähnlich wurde 5′-O-[N-(D-Alanyl)sulfamoyl]uridin (8) ausgehend von Boc-D-Ala-OSu und 2 hergestellt. Die Verbindungen 14 und 21 wurden direkt durch Sulfamoylierung der 4-N-(Dimethylamino)methylen-Derivate 13 und 20 von 2′,3′-O-Isopropylidencytidin bzw. 3′-O-Acetyl-2′-deoxy-5-methylcytidin über die 5′-O-Tributylzinn-Zwischenverbindungen dargestellt. Verbindung 20 wurde aus 5′-O-Isopropylidencytidin bzw. 3′-O-Acetyl-2′-deoxy-5-methylcytidin über die 5′-O-Tributylzinn-Zwischenverbindungen dargestellt. Verbindung 20 wurde aus 5′-O-(tert-Bu-tyldimethylsilyl)thymidin (17) mittels Acetylierung und nachfolgende Überführung des Thymidinrestes in 5-Methylcytosin über das entsprechende Triazolylpyrimidinon unter Schutz der Amidingruppe erhalten.
    Notes: Four analogues of ascamycin 〈5′-O-[N-(L-alanyl)sulfamoyl]-2-chloroadenosine〉 (1) in which the 2-chloroadenosine moiety has been replaced by uridine, thymidine, cytidine, and 2′-deoxy-5-methylcytidine have been synthesized by selective aminoacylation of the 5′-O-sulfamoyl derivatives 2, 9, 14, and 21 of 2′,3′-di-O-acetyluridine, 3′-O-acetylthymidine, 2′,3′-O-isopropylidenecytidine, and 3′-O-acetyl-2′-deoxy-5-methylcytidine, respectively, with Boc-L-Ala-OSu in DMF and in the presence of DBU, followed by removal of the protecting groups. Similarly, 5′-O-[N-(D-alanyl)sulfamoyl]uridine (8) has been prepared from Boc-D-Ala-OSu and 2. Compounds 14 and 21 were directly prepared by sulfamoylation of the 4-N-(dimethylamino)methylene derivatives 13 and 20 of 2′,3′-O-isopropylidenecytidine and 3′-O-acetyl-2′-deoxy-5-methylcytidine, respectively, via the intermediate 5′-O-tributyltin derivatives. Compound 20 was obtained from 5′-O-(tert-butyldimethylsilyl)thymidine (17) by a route involving acetylation, conversion of the thymidine moiety into 5-methylcytosine through the corresponding triazolylpyrimidinone, and amidine protection.
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  • 2
    Electronic Resource
    Electronic Resource
    Basel : Wiley-Blackwell
    Die Makromolekulare Chemie, Rapid Communications 9 (1988), S. 119-124 
    ISSN: 0173-2803
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1989), S. 553-557 
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Fast atom bombardment (FAB) mass spectrometry is, for the first time, successfully applied to the underivatized anthracycline antibiotics retamycins E1 and E2, using bis-(2-hydroxyethyl)sulphide as the matrix compound. The spectra are characterized by abundant protonated molecular ions and also by a number of sequence ions, which can be easily rationalized in terms of the carbohydrate sequence in the molecules. The relative abundance of these ions seems to depend on the functionalities close to the glycosidic oxygen, and also on their stereochemical relationship. Structural results are also confirmed by the analysis of the FAB mass spectra of the acetyl derivatives.
    Additional Material: 3 Ill.
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  • 4
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Base functionalization of saturated ethylene-propylene rubbers (EPR) was performed either by means of the radical grafting of 2-(dimethylamino)ethyl methacrylate onto EPR or by the reaction of a succinic anhydride grafted EPR with N,N-dimethylethylenediamine. Differences in the structure of the grafted molecules and in their thermal stability are also reported. An investigation is made on the reactivity of EPR having tertiary amino pendant groups toward acid functionalized EPR leading to gelation.
    Additional Material: 6 Ill.
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  • 5
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 189 (1988), S. 1207-1217 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The dynamic mechanical relaxations of poly(ethylene terephthalate) (PET), poly(1,4-cyclo-hexylenedimethylene terephthalate) (PCHDMT), and a copolymer of them (COP) were measured in the temperature range from -150 to 150°C by use of a dynamic viscoelastometer. The viscoelastic relaxations of COP are studied and compared with those of PET and PCHDMT. The anisotropy of the viscoelastic properties of stretched COP samples was also studied in order to distinguish between main and secondary relaxations.
    Additional Material: 8 Ill.
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  • 6
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The phonon spectra of thioanisole have been measured in a temperature range from the freezing point to 77 K, in order to ascertain if disordered crystalline phases are obtained as in other sulphur-containing molecular crystals studied. All the Davidov splitting components have been assigned on the basis of a correlation diagram which has been constructed assuming a unit cell isomorphous with a Cmc21 orthorhombic crystal.
    Additional Material: 4 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 423-428 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Vibrational spectra of 2-cyanothiophene in the solid state reveal that the crystals are ordered below the freezing point and have an orthorhombic C2v unit cell. Intermolecular forces between the two molecules occupying the Bravais unit are not strong enough to promote the separation of all the Davidov doublets of the phonon states.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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