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  • 1
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    Charcoal records of two sediment cores off SW Africa (2012)
    PANGAEA
    In:  Supplement to: Daniau, Anne-Laure; Bartlein, Patrick J; Harrison, S P; Prentice, Iain Colin; Brewer, Simon; Friedlingstein, Pierre; Harrison-Prentice, T I; Inoue, J; Izumi, K; Marlon, Jennifer R; Mooney, Scott D; Power, Mitchell J; Stevenson, J; Tinner, Willy; Andric, M; Atanassova, J; Behling, Hermann; Black, M; Blarquez, O; Brown, K J; Carcaillet, C; Colhoun, Eric A; Colombaroli, Daniele; Davis, Basil A S; D'Costa, D; Dodson, John; Dupont, Lydie M; Eshetu, Z; Gavin, D G; Genries, A; Haberle, Simon G; Hallett, D J; Hope, Geoffrey; Horn, S P; Kassa, T G; Katamura, F; Kennedy, L M; Kershaw, A Peter; Krivonogov, S; Long, C; Magri, Donatella; Marinova, E; McKenzie, G Merna; Moreno, P I; Moss, Patrick T; Neumann, F H; Norstrom, E; Paitre, C; Rius, D; Roberts, Neil; Robinson, G S; Sasaki, N; Scott, Louis; Takahara, H; Terwilliger, V; Thevenon, Florian; Turner, R; Valsecchi, V G; Vannière, Boris; Walsh, M; Williams, N; Zhang, Yancheng (2012): Predictability of biomass burning in response to climate changes. Global Biogeochemical Cycles, 26(4), https://doi.org/10.1029/2011GB004249
    Details
    Publication Date: 2024-01-13
    Description: We analyze sedimentary charcoal records to show that the changes in fire regime over the past 21,000 yrs are predictable from changes in regional climates. Analyses of paleo- fire data show that fire increases monotonically with changes in temperature and peaks at intermediate moisture levels, and that temperature is quantitatively the most important driver of changes in biomass burning over the past 21,000 yrs. Given that a similar relationship between climate drivers and fire emerges from analyses of the interannual variability in biomass burning shown by remote-sensing observations of month-by-month burnt area between 1996 and 2008, our results signal a serious cause for concern in the face of continuing global warming.
    Keywords: Center for Marine Environmental Sciences; MARUM
    Type: Dataset
    Format: application/zip, 2 datasets
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    DATA PANGAEA
  • 2
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    Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-10-13
    Description: Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold diagnostic and prognostic value. We developed a strategy that can be used to explore the origin of cancer-associated mutational signatures. We used CRISPR-Cas9 technology to delete key DNA repair genes in human colon organoids, followed by delayed subcloning and whole-genome sequencing. We found that mutation accumulation in organoids deficient in the mismatch repair gene MLH1 is driven by replication errors and accurately models the mutation profiles observed in mismatch repair–deficient colorectal cancers. Application of this strategy to the cancer predisposition gene NTHL1 , which encodes a base excision repair protein, revealed a mutational footprint (signature 30) previously observed in a breast cancer cohort. We show that signature 30 can arise from germline NTHL1 mutations.
    Keywords: Genetics, Medicine, Diseases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
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