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  • Cell Nucleolus/drug effects/metabolism  (1)
  • Spacecraft Design, Testing and Performance
  • 2005-2009  (2)
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  • 1
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    Dynamic proteomics of individual cancer cells in response to a drug (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-11-22
    Description: Why do seemingly identical cells respond differently to a drug? To address this, we studied the dynamics and variability of the protein response of human cancer cells to a chemotherapy drug, camptothecin. We present a dynamic-proteomics approach that measures the levels and locations of nearly 1000 different endogenously tagged proteins in individual living cells at high temporal resolution. All cells show rapid translocation of proteins specific to the drug mechanism, including the drug target (topoisomerase-1), and slower, wide-ranging temporal waves of protein degradation and accumulation. However, the cells differ in the behavior of a subset of proteins. We identify proteins whose dynamics differ widely between cells, in a way that corresponds to the outcomes-cell death or survival. This opens the way to understanding molecular responses to drugs in individual cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, A A -- Geva-Zatorsky, N -- Eden, E -- Frenkel-Morgenstern, M -- Issaeva, I -- Sigal, A -- Milo, R -- Cohen-Saidon, C -- Liron, Y -- Kam, Z -- Cohen, L -- Danon, T -- Perzov, N -- Alon, U -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1511-6. doi: 10.1126/science.1160165. Epub 2008 Nov 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel. ariel.cohen@weizmann.ac.il〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19023046" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Agents, Phytogenic/*pharmacology ; Camptothecin/*pharmacology ; Cell Death ; Cell Division/drug effects ; Cell Line, Tumor ; Cell Nucleolus/drug effects/metabolism ; Cell Nucleus/drug effects/metabolism ; Cell Survival/drug effects ; Cytoplasm/drug effects/metabolism ; DEAD-box RNA Helicases/metabolism ; DNA Damage ; DNA Topoisomerases, Type I/*metabolism ; Enzyme Inhibitors/pharmacology ; Fluorescence ; Humans ; Luminescent Proteins/metabolism ; Lung Neoplasms/*metabolism/*pathology ; Metabolic Networks and Pathways ; Oxidative Stress ; Proteins/*metabolism ; Proteome/*metabolism ; Proteomics ; Replication Protein C/metabolism ; Topoisomerase I Inhibitors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Fault Detection and Correction for the Solar Dynamics Observatory Attitude Control System (2007)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Solar Dynamics Observatory is an Explorer-class mission that will launch in early 2009. The spacecraft will operate in a geosynchronous orbit, sending data 24 hours a day to a devoted ground station in White Sands, New Mexico. It will carry a suite of instruments designed to observe the Sun in multiple wavelengths at unprecedented resolution. The Atmospheric Imaging Assembly includes four telescopes with focal plane CCDs that can image the full solar disk in four different visible wavelengths. The Extreme-ultraviolet Variability Experiment will collect time-correlated data on the activity of the Sun's corona. The Helioseismic and Magnetic Imager will enable study of pressure waves moving through the body of the Sun. The attitude control system on Solar Dynamics Observatory is responsible for four main phases of activity. The physical safety of the spacecraft after separation must be guaranteed. Fine attitude determination and control must be sufficient for instrument calibration maneuvers. The mission science mode requires 2-arcsecond control according to error signals provided by guide telescopes on the Atmospheric Imaging Assembly, one of the three instruments to be carried. Lastly, accurate execution of linear and angular momentum changes to the spacecraft must be provided for momentum management and orbit maintenance. In th~sp aper, single-fault tolerant fault detection and correction of the Solar Dynamics Observatory attitude control system is described. The attitude control hardware suite for the mission is catalogued, with special attention to redundancy at the hardware level. Four reaction wheels are used where any three are satisfactory. Four pairs of redundant thrusters are employed for orbit change maneuvers and momentum management. Three two-axis gyroscopes provide full redundancy for rate sensing. A digital Sun sensor and two autonomous star trackers provide two-out-of-three redundancy for fine attitude determination. The use of software to maximize chances of recovery from any hardware or software fault is detailed. A generic fault detection and correction software structure is used, allowing additions, deletions, and adjustments to fault detection and correction rules. This software structure is fed by in-line fault tests that are also able to take appropriate actions to avoid corruption of the data stream.
    Keywords: Spacecraft Design, Testing and Performance
    Type: AAS 2008 Guidance and Control (GN&C) Conference; Feb 01, 2008 - Feb 06, 2008; Breckenridge, Co; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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