Publication Date:
1981-04-17
Description:
In alcoholic liver injury, necrosis is involved in the progression from benign fatty liver to alcoholic hepatitis and cirrhosis. However, there is no practical model of alcohol-dependent liver cell necrosis. The calcium-dependent killing of cultured rat hepatocytes by two different membrane-active hepatotoxins, galactosamine and phalloidin, is potentiated by ethyl alcohol. This indicates that some general physical effect of alcohol on cellular membranes renders cells susceptible to otherwise nonlethal injuries. The in vitro model described in this report may thus be used to search for a general mechanism underlying alcohol-related tissue injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schanne, F A -- Zucker, A H -- Farber, J L -- Rubin, E -- AA 03442/AA/NIAAA NIH HHS/ -- AM 19154/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):338-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209533" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/pharmacology
;
Cell Membrane/drug effects
;
Cells, Cultured
;
Drug Synergism
;
Ethanol/pharmacology
;
Female
;
Galactosamine/pharmacology
;
In Vitro Techniques
;
Liver/drug effects
;
Liver Diseases, Alcoholic/*pathology
;
Necrosis
;
Phalloidine/pharmacology
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
