Publication Date:
2005-01-22
Description:
Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hwang, Eun Sook -- Szabo, Susanne J -- Schwartzberg, Pamela L -- Glimcher, Laurie H -- AI48126/AI/NIAID NIH HHS/ -- AI56296/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):430-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662016" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cell Lineage
;
Cytokines/pharmacology/physiology
;
DNA-Binding Proteins/chemistry/genetics/*metabolism
;
GATA3 Transcription Factor
;
Interleukin-5/genetics
;
Mice
;
Mice, Inbred BALB C
;
Mutation
;
Phosphorylation
;
Phosphotyrosine/metabolism
;
Promoter Regions, Genetic
;
Protein Structure, Tertiary
;
Protein-Tyrosine Kinases/metabolism
;
T-Box Domain Proteins
;
T-Lymphocytes, Helper-Inducer/cytology/*physiology
;
Th1 Cells/cytology/physiology
;
Th2 Cells/cytology/*physiology
;
Trans-Activators/chemistry/genetics/*metabolism
;
Transcription Factors/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
