Publication Date:
1995-09-15
Description:
Integrins regulate cell growth, differentiation, and behavior in many systems. Integrin beta 1C (beta 1S) is an alternatively spliced variant of integrin beta 1 with a specific cytoplasmic domain and is expressed in several human tissues. Human beta 1c transiently expressed in mouse 10T1/2 fibroblasts showed a diffuse pattern of cell surface staining, whereas beta1 localized to focal adhesions. Moderate concentrations of beta 1C had no effect on actin stress fibers or focal adhesions, but markedly inhibited DNA synthesis. Inhibition by beta 1C mapped to the late G1 phase of the cell cycle, near the G1-S boundary. Thus, alternative splicing of beta1 results in transmission of distinct signals that may regulate growth in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meredith, J Jr -- Takada, Y -- Fornaro, M -- Languino, L R -- Schwartz, M A -- P01 HL48728/HL/NHLBI NIH HHS/ -- R01 GM47214/GM/NIGMS NIH HHS/ -- R01GM47157/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1995 Sep 15;269(5230):1570-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7545312" target="_blank"〉PubMed〈/a〉
Keywords:
*Alternative Splicing
;
Amino Acid Sequence
;
Animals
;
Antigens, CD29
;
Cell Adhesion
;
Cell Division
;
Cell Line
;
Cell Size
;
DNA/biosynthesis
;
*G1 Phase
;
Humans
;
Integrins/chemistry/genetics/*physiology
;
Ligands
;
Mice
;
Molecular Sequence Data
;
Sequence Deletion
;
Signal Transduction
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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