Publication Date:
1983-11-04
Description:
The gene for glycoprotein D of herpes simplex virus type 1 (HSV-1) was expressed in stable mammalian cell lines. Glycoprotein D produced in these cells has a number of antigenic determinants in common with the native glycoprotein. Cell lines expressing glycoprotein D were used in an enzyme-linked immunosorbent assay to detect human antibodies to glycoprotein D. This strategy should prove useful in determining the extent to which the immune response to HSV-1 is directed toward glycoprotein D.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berman, P W -- Dowbenko, D -- Lasky, L A -- Simonsen, C C -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6312563" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Viral/*analysis
;
Base Sequence
;
Cell Line
;
Clone Cells
;
DNA Restriction Enzymes
;
DNA, Viral/genetics
;
Enzyme-Linked Immunosorbent Assay
;
*Genes
;
*Genes, Viral
;
Humans
;
Plasmids
;
Simplexvirus/genetics/*immunology
;
Tetrahydrofolate Dehydrogenase/genetics
;
*Viral Envelope Proteins
;
Viral Proteins/*genetics/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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