Publication Date:
2003-01-04
Description:
Neurogenesis occurs in the olfactory system of the adult brain throughout life, in both invertebrates and vertebrates, but its physiological regulation is not understood. We show that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin. The progenitors then migrate to produce new olfactory interneurons, a process likely to be important for maternal behavior, because olfactory discrimination is critical for recognition and rearing of offspring. Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shingo, Tetsuro -- Gregg, Christopher -- Enwere, Emeka -- Fujikawa, Hirokazu -- Hassam, Rozina -- Geary, Colleen -- Cross, James C -- Weiss, Samuel -- New York, N.Y. -- Science. 2003 Jan 3;299(5603):117-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genes & Development Research Group, Department of Cell Biology and Anatomy, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12511652" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cell Division
;
Cell Movement
;
Cells, Cultured
;
Choroid Plexus/metabolism
;
Dentate Gyrus/cytology
;
Epidermal Growth Factor/pharmacology
;
Estradiol/administration & dosage/pharmacology
;
Female
;
Interneurons/cytology/*physiology
;
Male
;
Mice
;
Neurons/cytology/*physiology
;
Olfactory Bulb/*cytology
;
Pregnancy
;
Progesterone/administration & dosage/pharmacology
;
Prolactin/administration & dosage/blood/pharmacology/*physiology
;
Prosencephalon/*cytology/*physiology
;
Pseudopregnancy
;
Receptors, Prolactin/genetics/metabolism
;
Signal Transduction
;
Stem Cells/*cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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