Publication Date:
2003-10-18
Description:
The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas Rac1-/- but not Rac2-/- HSC/Ps fail to engraft in the bone marrow of irradiated recipient mice. In contrast, Rac2, but not Rac1, regulates superoxide production and directed migration in neutrophils, and in each cell type, the two GTPases play distinct roles in actin organization, cell survival, and proliferation. Thus, Rac1 and Rac2 regulate unique aspects of hematopoietic development and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gu, Yi -- Filippi, Marie-Dominique -- Cancelas, Jose A -- Siefring, Jamie E -- Williams, Emily P -- Jasti, Aparna C -- Harris, Chad E -- Lee, Andrew W -- Prabhakar, Rethinasamy -- Atkinson, Simon J -- Kwiatkowski, David J -- Williams, David A -- DK62757/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 17;302(5644):445-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14564009" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/metabolism
;
Animals
;
Apoptosis
;
Bone Marrow Transplantation
;
Cell Adhesion
;
Cell Cycle
;
Cell Movement
;
Cell Size
;
Colony-Forming Units Assay
;
Cyclin D1/metabolism
;
Fibronectins/metabolism
;
Hematopoiesis
;
Hematopoietic Stem Cell Mobilization
;
Hematopoietic Stem Cell Transplantation
;
Hematopoietic Stem Cells/*physiology
;
Mice
;
Mice, Inbred NOD
;
Mice, SCID
;
Mitogen-Activated Protein Kinases/metabolism
;
Neutrophils/*physiology
;
*Protein-Serine-Threonine Kinases
;
Proto-Oncogene Proteins/metabolism
;
Proto-Oncogene Proteins c-akt
;
Recombination, Genetic
;
Signal Transduction
;
Stem Cell Factor/pharmacology
;
Superoxides/metabolism
;
rac GTP-Binding Proteins/genetics/*metabolism
;
rac1 GTP-Binding Protein/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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