ISSN:
0886-1544
Keywords:
stembody
;
microtubules
;
phosphorylation
;
midbody
;
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Medicine
Notes:
Phosphorylated proteins have been implicated in the control and regulation of many cellular events. One of the striking features of microtubule organizing centers is that they are rich in phosphoproteins [Vandre et al., 1984]. In this report we describe the application of electron spectroscopic imaging to the study of the spatial and temporal distribution of phosphorus and hence to the study of phosphorylated proteins associated with the formation and organization of one such organizing center, the intercellular bridge. Our study indicates that there are several discrete microtubule-based domains that ultimately come to lie within the intercellular bridge and that there is a unique pattern of phosphorylation-dephosphorylation in some of these domains. These patterns correlate with the concurrent growth and sliding of antiparallel microtubules and the development of interactions among neighboring microtubules.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cm.970110204
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