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  • 1
    Electronic Resource
    Electronic Resource
    Cellular transformation, tyrosine kinase oncogenes, and the cellular adhesion plaque (1988)
    New York, NY : Wiley-Blackwell
    BioEssays 8 (1988), S. 25-30 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The study of adhesion plaques in normal and transformed cells provides a series of phenotypic markers by which the process of transformation can be followed. Several proteins which are concentrated in adhesion plaques have now been identified; a few of these can act as targets for tyrosine kinase. In an attempt to characterize the relationship between tyrosine phosphorylation and cell transformation, the reactions of three such proteins - vinculin, talin and integrin - with a range of tyrosine kinase oncogene products have been studied in detail.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950080107
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Drosophila WARTS-tumor suppressor and member of the myotonic dystrophy protein kinase family (1995)
    New York, NY : Wiley-Blackwell
    BioEssays 17 (1995), S. 673-676 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Tumor suppressor genes represent a broad class of genes that normally function in the negative regulation of cell proliferation. Loss-of-function mutations in these genes lead to unrestrained cell proliferation and tumor formation. A fundamental understanding of how tumor suppressor genes regulate cell proliferation and differentiation should reveal important aspects of signalling pathways and cell cycle control. A recent report describing the Drosophila tumor suppressor gene warts has implications in the study of the human myotonic dystrophy gene(1). These genes encode members of a cyclic AMP-dependent protein kinase subfamily that includes other plant and animal orthologues.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950170803
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    Paper (German National Licenses)
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  • 3
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    The average X-ray/gamma-ray spectra of Seyfert galaxies from Ginga and OSSE and the origin of the cosmic X-ray background (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: We have obtained the first average 2-500 keV spectra of Seyfert galaxies, using the data from Ginga and Compton Gamma-Ray Observatory's (CGRO) Oriented Scintillation Spectrometer Experiment (OSSE). Our sample contains three classes of objects with markedly different spectra: radio-quiet Seyfert 1's and 2's, and radio-loud Seyfert 1's. The average radio-quiet Seyfert 1 spectrum is well-fitted by a power law continuum with the energy spectral index alpha approximately equals 0.9, a Compton reflection component corresponding to a approximately 2 pi covering solid angle, and ionized absorption. There is a high-energy cutoff in the incident power law continuum: the e-folding energy is E(sub c) approximately equals 0.6(sup +0.8 sub -0.3) MeV. The simplest model that describes this spectrum is Comptonization in a relativistic optically-thin thermal corona above the surface of an accretion disk. Radio-quiet Seyfert 2's show strong netural absorption, and there is an indication that their X-ray power laws are intrinsically harder. Finally, the radio-loud Seyfert spectrum has alpha approximately equals 0.7, moderate neutral absorption E(sub C) = 0.4(sup +0.7 sub -0.2) MeV, and no or little Compton reflection. This is incompatible with the radio-quiet Seyfert 1 spectrum, and probably indicating that the X-rays are beamed away from the accretion disk in these objects. The average spectra of Seyferts integrated over redshift with a power-law evolution can explain the hard X-ray spectrum of the cosmic background.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 438; 2; p. L63-L66
    Format: text
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