ISSN:
1573-739X
Keywords:
Cefoxitin
;
Ceftazidime
;
Ceftriaxone
;
Cefuroxime
;
Chromatography, high pressure liquid
;
Kidney diseases
;
Pharmacokinetics
;
Protein binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01960743
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