Publication Date:
1983-09-23
Description:
Sodium fluoride, guanylimidodiphosphate, and the D1 dopamine receptor agonist SKF 38393 elicited a greater activation of adenylate cyclase in homogenates of caudate nucleus in schizophrenic than in nonschizophrenic subjects used as controls. Similarly, a greater activation of adenylate cyclase by sodium fluoride was observed in the nucleus accumbens of schizophrenics. These findings suggest that the coupling of dopamine D1 recognition sites with adenylate cyclase is more efficient in the brain of the schizophrenic, presumably because of an increased affinity of the G/F protein for guanosine 5'-triphosphate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Memo, M -- Kleinman, J E -- Hanbauer, I -- MH/NS 31862/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1304-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310753" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/*metabolism
;
Caudate Nucleus/*metabolism
;
Enzyme Activation/drug effects
;
Fluorides/pharmacology
;
GTP-Binding Proteins
;
Guanylyl Imidodiphosphate/pharmacology
;
Humans
;
Membrane Proteins/metabolism
;
Nucleus Accumbens/*metabolism
;
Receptors, Cell Surface/*physiology
;
Receptors, Dopamine/*physiology
;
Schizophrenia/*metabolism
;
Septal Nuclei/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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