ISSN:
0947-3440
Keywords:
Molecular glycobiology
;
Oligosaccharides
;
Carbohydrates
;
Molecular recognition
;
Polyvalent receptor-ligand interaction
;
Enzyme inhibitors
;
Carbohydrate mimetics
;
Multienzyme synthesis
;
Carbohydrate synthesis
;
Recombinant enzymes
;
Glycosyltransferases
;
Glycosidases
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Carbohydrates are increasingly appreciated for their critical roles in biological functions. Driving these studies addressing the molecular basis of carbohydrate-mediated events is the availability of natural and unnatural carbohydrates. Recently, new methods of enzymatic synthesis have been developed that now afford rapid access to complex, structurally diverse oligosaccharides on large scales. This methodology has been essential to gaining insight into the molecular details of important carbohydrate recognition phenomena that are associated with many signaling processes. This review summarizes recent chemical studies examining selectin/sialyl Lewisx binding, a key event in inflammation and metastasis, and describes the development of carbohydrate mimetics that may offer leads to new therapeutic agents. In addition, combinatorial synthesis has been used to prepare carbohydrate mimetics to neomycin B, an aminoglycoside that binds RNA involved in HIV infection, and chemoenzymatic methodology has been applied to the design and synthesis of mechanism-based inhibitors of glycoprocessing enzymes.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719970604
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