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  • 1
    ISSN: 1573-739X
    Keywords: Clindamycin ; Cost‐effectiveness ; Intravenous‐to‐oral step‐down ; Sequential therapy ; Switch therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A multicentre, prospective, controlled study compared the clinical efficacy, safety and economic impact of a pharmacist intervention to promote sequential intravenous to oral clindamycin conversion. A total of 473 patients receiving intravenous clindamycin for at least 72 hours were included in the study. Two groups were established: an intervention group (204 patients) in which an informative sheet recommending the sequential treatment was provided, and a control group (269 patients). Clindamycin was prescribed for respiratory infections in 38.9% and for prophylaxis in surgery in 25.4% of the patients (71% were contaminated surgery). No difference between groups regarding sex, infection severity, health status or clinical progress was observed. Both the step‐down treatments after 72 hours of intravenous clindamycin and the change to the oral route later on, were significantly increased with the intervention (p〈0.001, p〈0.001 respectively). No significant differences between both groups were found in the number of patients with adverse effects associated with the IV therapy, although the incidence tended to be lower in the intervention group (49/204 intervention versus 85/269 control, p=0.07). Compliance with the recommended clindamycin dosing regimen was significantly higher in the intervention group, in which 1.3 days reduction of intravenous therapy provided an average cost savings of PTA5246 (95%CI 2556‐7935) per treatment. A higher reduction of 1.7 days was achieved in those patients candidates for switch therapy on the third day of intravenous clindamycin. A sequential program with clindamycin may provide a cost‐effective alternative to conventional therapy and the introduction of an information sheet is a cost‐effective strategy to promote it.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2021-05-19
    Description: La presencia del mejillón verde (Perna viridis) se reporta a partir de 2005 en la bahía de Cienfuegos de Cuba. El presente estudio se realizó para determinar la calidad microbiológica de los ejemplares que habitan en las dos áreas de mayor abundancia de P. viridisen la bahía de Cienfuegos, durante los períodos de lluvia y seca. En las muestras de mejillones no se detectaron Vibrio parahaemolyticus, Vibrio cholerae ni Staphyllococcus aureus coagulasa + y los conteos de mesófilos aerobios fueron bajos (1,7 x 10 2 ; 2,1 x 10 3 ; 1,4 x 10 3 ; 2,2 x 10 2 ; 3,3 x 10 2 y 2,6 x 10 2 en 2010 y 5,4 x 10; 5,1 x 10 3 ; 2,0 x 10 3 y 3,2 x 10 2 en 2011), pero todas estaban contaminadas por Escherichia coliy coliformes fecales (360; 280; 230 y 40 en 2010 y 70; 90; 680 y 〈 18 en 2011), con valores superiores en septiembre de 2010 (1 500 y 4 600), donde también se comprobó la presencia de una cepa de Salmonella choleraesuis,que no volvió a aparecer en el resto del estudio. La calidad microbiológica del agua de las áreas estudiadas, no permite establecer en ellas la comercialización del producto fresco sin tratamiento previo, ya que están contaminadas por Escherichia coliy coliformes totales y fecales.
    Description: The presence of green mussels (Perna viridis) has been reported from 2005 in Cienfuegos bay, Cuba. This study was made to determine the microbiological quality of the specimens that inhabit in the two areas of Cienfuegos bay in which this specie is more abundant in dry and rain periods. The microbiological quality of the water of the studied areas, doesn’t allow using them as production areas of P. viridissince they are very contaminated by Escherichia coli and total and fecal coliforms. Vibrio parahaemolyticus, Vibrio cholerae and Staphyllococcus aureus coagulasa+ were not detected in mussels and the aerobic mesophilic counts were low (1,7 x 10 2 ; 2,1 x 10 3 ; 1,4 x 10 3 ; 2,2 x 10 2 ; 3,3 x 10 2 and 2,6 x 10 2 in 2010 and 5,4 x 10; 5,1 x 10 3 ; 2,0 x 10 3 and 3,2 x 10 2 in 2011), but they were contaminated by Escherichia coli and fecal coliformes (360; 280; 230 and 40 in 2010 and 70; 90; 680 and 〈 18 in 2011), with highly values in September 2010 (1 500 and 4 600), when we found a strain of Salmonella choleraesuis that didn’t appear in the rest of the study. The microbiological quality of the studied specimens, doesn’t allow its commercialization in a fresh way, without any treatment.
    Description: Published
    Keywords: Mejillón verde ; Perna viridis ; Calidad microbiológica ; Green lipped mussel ; Microbiological quality
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed
    Format: pp.23-29
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