ISSN:
1573-739X
Keywords:
Arrhythmia
;
Calcium
;
Calmodulin/antagonists & inhibitors
;
Cardiomyopathy, congestive
;
Drug therapy
;
Gastrointestinal diseases
;
Hypertension
;
Neoplasms
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Calmodulin is the most important intracellular receptor protein for the second messenger calcium. The calcium-calmodulin complex regulates a number of physiological processes. An increasing number of pharmaceutical products is reported to interfere with the calcium-calmodulin complex. Despite the fact that the precise mechanisms of action of these so-called calmodulin antagonists await further clarification, reports accumulate in the literature indicating a broadening spectrum of putative therapeutic applications of calmodulin antagonists. Some of these applications, such as in cell proliferation, hypertension, congestive heart failure, arrhythmia and gastro-intestinal disorders, are discussed in the present review.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01962532
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