Publication Date:
1991-01-11
Description:
Synaptic transmission was examined in Drosophila mutants deficient in memory function. These mutants, dunce and rutabaga, are defective in different steps of the cyclic adenosine 3',5'-monophosphate (cAMP) cascade. In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP. In addition, the calcium dependence of transmitter release was shifted in dunce. The results suggest that the cAMP cascade plays a role in synaptic facilitation and potentiation and indicate that synaptic plasticity is altered in Drosophila memory mutants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhong, Y -- Wu, C F -- New York, N.Y. -- Science. 1991 Jan 11;251(4990):198-201.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Iowa, Iowa City 52242.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1670967" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials/drug effects
;
Animals
;
Bucladesine/pharmacology
;
Calcium/pharmacology
;
Cyclic AMP/*physiology
;
Drosophila/*genetics
;
Electric Stimulation
;
Larva/physiology
;
Memory/physiology
;
Muscle Contraction/physiology
;
Mutation
;
Neuromuscular Junction/physiology
;
Neuronal Plasticity/*physiology
;
Neurotransmitter Agents/secretion
;
Synapses/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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