ISSN:
1573-4927
Keywords:
pancreas protease
;
chymotrypsin A
;
CTRA-1
;
mouse genetics
;
chromosome 8
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characterized by the absence of a corresponding protease band. A third phenotype, CTRA-1C, was observed in IS/Cam and a fourth phenotype, CTRA-1D, was detected in SEG/1. CTRA-1 was found only in the pancreas and may represent the A form of chymotrypsin. The enzyme was shown to be controlled by the presumed structural locusCtra-1 located on chromosome 8. From two backcross series, including a total of 274 animals, the gene order(Es-1, Es-9)—3.9±1.7%—Got-2—3.9±1.7%—(Es-2, Es-7, Es-23)—0.7±0.5%—Ctra-1—6.3±2.2%—Prt-2 was established.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00554129
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