ISSN:
1432-1327
Keywords:
Key-words Methane monooxygenase
;
C-H activation
;
Diiron site
;
Quantum mechanical calculations
;
Protein structure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The diiron site of methane monooxygenase (MMO) has the unique ability to activate methane. Structural studies of the MMO diiron site have revealed a limited number of coordination sites for dioxygen and dioxygen derived species. Using quantum mechanical studies of the MMO reaction, several possible reaction paths have been investigated. Energetically feasible geometries have been obtained for the different reaction steps, where the substrate activation is best described by an almost pure hydrogen abstraction step, followed by the formation of a metal-carbon bond.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007750050238
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