Publication Date:
1996-12-20
Description:
Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3',5' monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein alpha subunit (Galphas*) was targeted to these brain structures. The ability to associate odors with electroshock was abolished when Galphas* was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal. Expression of Galphas* did not affect gross MB morphology, and wild-type Galphas expression did not affect learning. Thus, olfactory learning depends on regulated Gs signaling in Drosophila MBs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Connolly, J B -- Roberts, I J -- Armstrong, J D -- Kaiser, K -- Forte, M -- Tully, T -- O'Kane, C J -- HD 32245/HD/NICHD NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1996 Dec 20;274(5295):2104-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. connollj@cshl.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8953046" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/metabolism
;
Animals
;
Brain/anatomy & histology/metabolism
;
*Conditioning (Psychology)
;
Drosophila/*metabolism
;
Electroshock
;
GTP-Binding Protein alpha Subunits, Gs/genetics/*metabolism
;
Guanosine Triphosphate/metabolism
;
Neurons/*metabolism
;
Odors
;
*Signal Transduction
;
Smell/physiology
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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