Publication Date:
1992-12-11
Description:
Infection with the human immunodeficiency virus (HIV) is frequently accompanied by the AIDS (acquired immunodeficiency syndrome) dementia complex. The role of specific HIV genetic elements in the pathogenesis of central nervous system (CNS) disease is not clear. Transgenic mice were constructed that contained the long terminal repeats (LTRs) of two CNS-derived strains and a T cell tropic strain of HIV-1. Only mice generated with CNS-derived LTRs directed expression in the CNS, particularly in neurons. Thus, some strains of HIV-1 have a selective advantage for gene expression in the brain, and neurons can supply the cellular factors necessary for their transcription.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corboy, J R -- Buzy, J M -- Zink, M C -- Clements, J E -- AI27297/AI/NIAID NIH HHS/ -- AI28748/AI/NIAID NIH HHS/ -- NS07000/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Dec 11;258(5089):1804-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1465618" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*physiology
;
Central Nervous System/*physiology
;
Female
;
Gene Expression
;
*HIV Long Terminal Repeat
;
HIV-1/*genetics
;
Intestine, Small/physiology
;
Lung/physiology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Inbred DBA
;
Mice, Transgenic
;
Ocular Physiological Phenomena
;
Organ Specificity
;
RNA, Messenger/analysis/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Spinal Cord/physiology
;
Thymus Gland/physiology
;
beta-Galactosidase/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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