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  • IBA  (3)
  • Bone Gla protein  (2)
  • Springer  (5)
  • Nature Publishing Group
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  • Springer  (5)
  • Nature Publishing Group
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  • 1
    Electronic Resource
    Electronic Resource
    The effect of a new vitamin D analog, 22-oxa-1α,25(OH)2D3, on bone mineral metabolism in normal male rats (1992)
    Springer
    Calcified tissue international 50 (1992), S. 521-523 
    Details
    ISSN: 1432-0827
    Keywords: 22-oxa-1α, 25 Dihydroxyvitamin D3 ; 1,25(OH)2D3 ; Bone histomorphometry ; Bone Gla protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Thein vivo effects of 22-oxa-1α, 25 dihydroxyvitamin D3 (OCT), on bone mineral metabolism were investigated in normal male Sprague-Dawley rats. The rats were administered either vehicle (control), low-dose OCT (25 ng/100 g body weight), or high-dose OCT (250 ng/100 g body wt). High-dose OCT increased serum ionized calcium (P〈0.05) and decreased serum parathyroid hormone (PTH) (P〈0.05) at all time points and increased serum bone Gla protein on days 7 and 28 (P〈0.05) compared with controls. Lowdose OCT decreased serum PTH at all the time points (P〈0.05) compared with controls. Tibial bone histomorphometry showed no significant differences between the two doses of OCT and controls. We found that OCT has minimal direct effects on bone metabolism in normal male rats in contrast to 1,25 dihydroxyvitamin D3. This property may be advantageous in the treatment with OCT of cell-proliferative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582166
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of change of cancellous bone volume with short-term use of the new immunosuppressant rapamycin in rats (1993)
    Springer
    Calcified tissue international 53 (1993), S. 45-52 
    Details
    ISSN: 1432-0827
    Keywords: Rapamycin ; Bone mineral metabolism ; Bone Gla protein ; Immunosuppressants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Immunosuppressants have adverse effects on bone mineral metabolism in animal and human studies, with corticosteroids producing low-turnover osteopenia, and cyclosporin-A (CsA) producing high-turnover osteopenia. Rapamycin (RAPA) is a new immunosuppressant reported to be at least 10 times more potent than CsA, and acts via a different pathway to CsA and the other new immunosuppressant FK506. This study investigated the effects of RAPA on bone mineral metabolism in the rat. Forty-two, 10-week-old, male Sprague Dawley rats were divided into three groups, and treated according to the following protocol: group A (control) received RAPA vehicle by daily gavage for 14 days (n = 12); group B (high dose RAPA) received RAPA 2.5 mg/kg/day by daily gavage for 14 days (n = 15); group C (low dose RAPA) received RAPA 1.25 mg/kg/day by daily gavage for 14 days (n = 15). Rats were weighed and bled on days 0, 7, and 14 for measurement of blood ionized calcium, bone Gla protein (BGP), parathyroid hormone (PTH), and 1,25(OH)2D. Tibial bone histomorphometry was determined on day 14 after double-calcein labeling. Weight gain was similar in the two groups treated with RAPA compared with control animals. High-dose RAPA (group B) transiently depressed serum BGP levels on day 7, with elevated blood ionized calcium levels on day 7, and lowered 1,25(OH)2D levels on day 14. Serum PTH levels were unchanged. Low dose RAPA (group C) did not affect calciotropic hormones. Histomorphometric analyses of tibial metaphyses revealed that parameters of bone formation and resorption were not significantly different in the groups treated with RAPA (group B and C) compared with control animals (group A). Trabecular bone volume (BV/TV) in group B (high-dose RAPA) (15.39 ± 1.01%) and C (low-dose RAPA) (15.38 ±0.57%) was not significantly altered compared with group A (control) (16.42 ± 0.86%). Short-term treatment with RAPA, unlike CsA, does not result in excess resorption and loss of bone volume. The depressed serum 1,25(OH)2D levels seen with high-dose RAPA therapy may adversely effect bone mineral metabolism in the long term.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01352014
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of indole-3-butyric acid as an endogenous constituent of maize kernels and leaves (1989)
    Springer
    Plant growth regulation 8 (1989), S. 215-223 
    Details
    ISSN: 1573-5087
    Keywords: IAA ; IBA ; conjugated IBA ; rooting ; Zea mays
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Indole-3-butyric acid (IBA) was identified by thin layer chromatography, gas-liquid chromatography and gas chromatography-mass spectrometry in kernels and leaves of corn (Zea mays) var. Hazera 224. Free and ester conjugated IBA were present in dry and germinating corn kernels and leaves. This is the first report of IBA in a monocotyledonous plant and, as far as we know, the first evidence for the presence of conjugated IBA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00025391
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of ethylene treatment on transport and metabolism of indole-3-butyric acid in citrus leaf midribs (1992)
    Springer
    Plant growth regulation 11 (1992), S. 357-362 
    Details
    ISSN: 1573-5087
    Keywords: Citrus ; conjugation ; ethylene ; IAA ; IBA ; polar transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Transport and metabolism of radiolabeled indole-3-butyric acid (IBA) were studied in midrib sections of Cleopatra mandarin (Citrus reticulata Blanco) and compared to that of indole-3-acetic acid (IAA). Exogenous IBA was metabolized by the midribs to a polar compound, probably an ester conjugate. Ethylene pretreatment of the midribs reduced their capacity to metabolize IBA by ca. 70% as compared to air pretreatment. IBA transport capacity in the leaf midribs was ca. two times greater in the basipetal direction than the acropetal. The basipetal transport capacity of 3H-IBA was lower than that of 14C-IAA (ca. 24% and 39% of the uptake, respectively). While ethylene treatment reduced basipetal transport of IAA by ca. 70% it did not affect the transport of IBA. Most of the transported label was found as free IBA, but the reduction of IBA conjugation by ethylene treatment did not affect the transport capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00130642
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  • 5
    Electronic Resource
    Electronic Resource
    Biosynthesis of plant hormones during anaerobic digestion of instant coffee waste (1995)
    Springer
    Plant growth regulation 17 (1995), S. 127-132 
    Details
    ISSN: 1573-5087
    Keywords: anaerobic methanogenic thermophilic digestion ; auxin ; biogas ; IAA ; IBA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract A large amount of solid waste remains after the production of instant coffee. This waste has to be moved to dumps, where it poses a threat of environmental pollution. Treatment of this waste by anaerobic methanogenic thermophilic digestion produced, besides biogas, a digested slurry which was used as a growth medium for horticulture, and proved to be a suitable and economical substitute for peat moss. Biological tests with mung bean cuttings and Grevillea plantlets showed promotional effects on rooting of the slurry and its sieved fraction extract, washed with water (Capul). Green coffee beans, instant coffee waste, its anaerobically-digested slurry and Capul were extracted by various methods and the extracts were analyzed by TLC, HPLC and GC/MS. Examinations showed clearly the presence of IAA and IBA in free and bound forms in all the substrates. The values of free and bound IAA were calculated by use of an internal standard and GC/MS. The amount of conjugated IAA was found to be much higher than that of free IAA, in both the coffee beans and instant coffee waste (11.1 vs 2.7 nmol g−1, respectively). In the digested slurry and Capul, however, most of the IAA was present as the free form and was approximately 23.5–33.0 nmol g−1, which is almost ten times more than in the waste, and almost twice the total amount of IAA in coffee beans. It is postulated that the high levels of free IAA in the digested instant coffee waste are a result of catabolism of tryptophan by anaerobic bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00024172
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