ISSN:
0009-2940
Keywords:
Bond formation
;
C—C / Host-Guest complexation
;
Metacyclophanes
;
Conformation, syn, anti
;
Hagihara coupling
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Molecular Tweezers from Cyclophane Building BlocksMolecular tweezer compounds 1-6 with convergent carboxyl groups are prepared from suitable functionalized [2.2]-and dithia[3.3]metacyclophane building blocks by using several multistep strategies. The C—C coupling of two cyclophanes according to the Hagihara method leads to alkynespacered double cyclophanes. These new preorganized, acyclic host compounds of the cyclophane-type react as molecular tweezers and can selectively “grasp” guest molecules and bind them strongly. X-ray analyses underline the syn conformations of the dithia[3.3]- and the anti conformation of the [2.2]metacyclophanes.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19941270426
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