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  • 1
    Electronic Resource
    Electronic Resource
    State of the hypothalamic-pituitary neurosecretory system in rabbits with anaphylactic shock (1975)
    Springer
    Bulletin of experimental biology and medicine 80 (1975), S. 955-958 
    Details
    ISSN: 1573-8221
    Keywords: anaphylactic shock ; neurosecretion ; hypothalamic-pituitary system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The hypothalamic-pituitary neurosecretory system of rabbits with anaphylactic shock was investigated by morphometric and histochemical methods. The volumes of the perikarya were increased and the dimensions of the nuclei and nucleoli of the neurosecretory cells were reduced, and the content of neurosecretory substance throughout the neurosecretory system was increased. In rabbits dying from shock the volumes of the nuclei and nucleoli were reduced by a lesser degree, the dimensions of the perikarya were changed, and the content of neurosecretory substance in the posterior lobe of the pituitary was reduced. In animals surviving shock the synthesis of neurohormones by the neurosecretory cells was thus sharply stimulated, but liberation of neurohormones from the posterior lobe was inhibited. In animals dying from shock hormone formation in the neurosecretory cells was stimulated to a lesser degree, but the processes of liberation of neurohormones from the posterior lobe of the pituitary were probably intensified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789280
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    State of the hypothalamic-pituitary neurosecretory system in rabbits with anaphylactic shock (1976)
    Springer
    Neuroscience and behavioral physiology 7 (1976), S. 1-4 
    Details
    ISSN: 1573-899X
    Keywords: anaphylactic shock ; neurosecretion ; hypothalamic-pituitary system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The hypothalamic-pituitary neurosecretory system of rabbits with anaphylactic shock was investigated by morphometric and histochemical methods. The volumes of the perikarya were increased and the dimensions of the nuclei and nucleoli of the neurosecretory cells were reduced, and the content of neuro-secretory substance throughout the neurosecretory system was increased. In rabbits dying from shock the volumes of the nuclei and nucleoli were reduced by a lesser degree, the dimensions of the perikarya were changed, and the content of neurosecretory substance in the posterior lobe of the pituitary was reduced. In animals surviving shock the synthesis of neurohormones by the neurosecretory cells was thus sharply stimulated, but liberation of neurohormones from the posterior lobe was inhibited. In animals dying from shock hormone formation in the neurosecretory cells was stimulated to a lesser degree, but the processes of liberation of neurohormones from the posterior lobe of the pituitary were probably intensified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01148738
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    Paper (German National Licenses)
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  • 3
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    Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-04-11
    Description: Aneuploidy, the inheritance of an atypical chromosome complement, is common in early human development and is the primary cause of pregnancy loss. By screening day-3 embryos during in vitro fertilization cycles, we identified an association between aneuploidy of putative mitotic origin and linked genetic variants on chromosome 4 of maternal genomes. This associated region contains a candidate gene, Polo-like kinase 4 (PLK4), that plays a well-characterized role in centriole duplication and has the ability to alter mitotic fidelity upon minor dysregulation. Mothers with the high-risk genotypes contributed fewer embryos for testing at day 5, suggesting that their embryos are less likely to survive to blastocyst formation. The associated region coincides with a signature of a selective sweep in ancient humans, suggesting that the causal variant was either the target of selection or hitchhiked to substantial frequency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCoy, Rajiv C -- Demko, Zachary -- Ryan, Allison -- Banjevic, Milena -- Hill, Matthew -- Sigurjonsson, Styrmir -- Rabinowitz, Matthew -- Fraser, Hunter B -- Petrov, Dmitri A -- R01 GM089926/GM/NIGMS NIH HHS/ -- R01 GM097415/GM/NIGMS NIH HHS/ -- R01 GM100366/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 Apr 10;348(6231):235-8. doi: 10.1126/science.aaa3337.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Stanford University, Stanford, CA, USA. ; Natera, Inc., San Carlos, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25859044" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; *Aneuploidy ; Blastomeres ; Embryo, Mammalian/*physiology ; Embryonic Development ; Fathers ; Female ; Fertilization in Vitro ; Genetic Association Studies ; Genetic Testing ; Haplotypes ; Humans ; Male ; *Mitosis ; Mothers ; Phenotype ; *Polymorphism, Single Nucleotide ; Protein-Serine-Threonine Kinases/*genetics/physiology ; Selection, Genetic ; Trophoblasts
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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