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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 79 (1995), S. 483-490 
    ISSN: 1572-9613
    Keywords: Biological aging ; Dauer state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Here we present generalizations of a recently proposed aging model to include several ages and the “Dauer” state. The results show that increasing the number of ages does not matter in one version of the model, but matters in another version, and that the Dauer state does provide a favorable mechanism for survival.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5001
    Keywords: AIDS ; DYANA ; HIV-1 ; NMR structure ; ribonuclease H ; RNA-DNA hybrid ; torsion angle dynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A high-quality NMR solution structure of the chimeric hybrid duplex r(gcaguggc)⋅r(gcca)d(CTGC) was determined using the program DYANA with its recently implemented new module FOUND, which performs exhaustive conformational grid searches for dinucleotides. To ensure conservative data interpretation, the use of 1H-1H lower distance limit constraints was avoided. The duplex comprises the tRNA–DNA junction formed during the initiation of HIV-1 reverse transcription. It forms an A-type double helix that exhibits distinct structural deviations from a standard A-conformation. In particular, the minor groove is remarkably narrow, and its width decreases from about 7.5 Å in the RNA/RNA stem to about 4.5 Å in the RNA/DNA segment. This is unexpected, since minor groove widths for A-RNA and RNA/DNA hybrid duplexes of ∼11 Å and ∼8.5 Å, respectively, were previously reported. The present, new structure supports that reverse transcriptase-associated RNaseH specificity is related primarily to conformational adaptability of the nucleic acid in 'induced-fit'-type interactions, rather than the minor groove width of a predominantly static nucleic acid duplex.
    Type of Medium: Electronic Resource
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