Publication Date:
1998-02-07
Description:
In order to reach the inner membrane of the mitochondrion, multispanning carrier proteins must cross the aqueous intermembrane space. Two essential proteins of that space, Tim10p and Tim12p, were shown to mediate import of multispanning carriers into the inner membrane. Both proteins formed a complex with the inner membrane protein Tim22p. Tim10p readily dissociated from the complex and was required to transport carrier precursors across the outer membrane; Tim12p was firmly bound to Tim22p and mediated the insertion of carriers into the inner membrane. Neither protein was required for protein import into the other mitochondrial compartments. Both proteins may function as intermembrane space chaperones for the highly insoluble carrier proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koehler, C M -- Jarosch, E -- Tokatlidis, K -- Schmid, K -- Schweyen, R J -- Schatz, G -- New York, N.Y. -- Science. 1998 Jan 16;279(5349):369-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9430585" target="_blank"〉PubMed〈/a〉
Keywords:
Biological Transport
;
Carrier Proteins/*metabolism
;
Cloning, Molecular
;
Fungal Proteins/genetics/*metabolism
;
Genes, Fungal
;
Hot Temperature
;
Intracellular Membranes/*metabolism
;
Membrane Potentials
;
Membrane Proteins/genetics/*metabolism
;
*Membrane Transport Proteins
;
Mitochondria/*metabolism
;
Mitochondrial ADP, ATP Translocases/metabolism
;
Mitochondrial Membrane Transport Proteins
;
Models, Biological
;
Molecular Chaperones/metabolism
;
Mutagenesis
;
Phosphate-Binding Proteins
;
Saccharomyces cerevisiae/genetics/metabolism
;
*Saccharomyces cerevisiae Proteins
;
Solubility
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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