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    Trophic conversion of an obligate photoautotrophic organism through metabolic engineering (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-16
    Description: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically derived energy. We show that the microalga Phaeodactylum tricornutum can be genetically engineered to thrive on exogenous glucose in the absence of light through the introduction of a gene encoding a glucose transporter (glut1 or hup1). This demonstrates that a fundamental change in the metabolism of an organism can be accomplished through the introduction of a single gene. This also represents progress toward the use of fermentation technology for large-scale commercial exploitation of algae by reducing limitations associated with light-dependent growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaslavskaia, L A -- Lippmeier, J C -- Shih, C -- Ehrhardt, D -- Grossman, A R -- Apt, K E -- New York, N.Y. -- Science. 2001 Jun 15;292(5524):2073-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Martek Biosciences Corp., 6480 Dobbin Road, Columbia, MD 21045, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11408656" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Cell Line, Transformed ; Cell Membrane/metabolism ; Darkness ; Diatoms/*genetics/growth & development/*metabolism ; *Genetic Engineering ; Glucose/*metabolism ; Glucose Transporter Type 1 ; Glycolysis ; Green Fluorescent Proteins ; Humans ; Light ; Luminescent Proteins/genetics/metabolism ; Membrane Proteins/genetics/metabolism ; Microscopy, Confocal ; Molecular Weight ; Monosaccharide Transport Proteins/chemistry/*genetics/metabolism ; Photosynthesis ; Recombinant Fusion Proteins/metabolism ; Symporters ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Visualization of cellulose synthase demonstrates functional association with microtubules (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-22
    Description: Expression of a functional yellow fluorescent protein fusion to cellulose synthase (CESA) in transgenic Arabidopsis plants allowed the process of cellulose deposition to be visualized in living cells. Spinning disk confocal microscopy revealed that CESA complexes in the plasma membrane moved at constant rates in linear tracks that were aligned and were coincident with cortical microtubules. Within each observed linear track, complex movement was bidirectional. Inhibition of microtubule polymerization changed the fine-scale distribution and pattern of moving CESA complexes in the membrane, indicating a relatively direct mechanism for guidance of cellulose deposition by the cytoskeleton.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paredez, Alexander R -- Somerville, Christopher R -- Ehrhardt, David W -- New York, N.Y. -- Science. 2006 Jun 9;312(5779):1491-5. Epub 2006 Apr 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, 260 Panama Street, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16627697" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/enzymology/*physiology ; Arabidopsis Proteins/antagonists & inhibitors/genetics/*metabolism ; Benzamides/pharmacology ; Biological Transport ; Cell Membrane/metabolism ; Cellulose/*metabolism ; Enzyme Inhibitors/pharmacology ; Glucosyltransferases/antagonists & inhibitors/genetics/*metabolism ; Microfibrils/metabolism ; Microscopy, Confocal ; Microtubules/*physiology ; Plants, Genetically Modified ; Recombinant Fusion Proteins/genetics/metabolism ; Tubulin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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