Publication Date:
1978-02-03
Description:
Isoproterenol doses not elicit its characteristic positive inotropic action in contracting guinea pig atria suspended in sodium-free media. However, the ability of isoproterenol to decrease the time to peak tension development during an individual contraction cycle is still present in sodium-free solutions. Removal of sodium diminished but did not eliminate the tissues' ability to elevate adenosine 3',5'-monophosphate in response to isoproterenol. The striking absence of an inotropic action by isoproterenol on atria in sodium-free media suggests that sodium (and possibly a sodium-calcium exchange across the sarcolemma) plays an important role in the inotropic action of catecholamines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linden, J -- Brooker, G -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):539-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203031" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biological Transport/drug effects
;
Calcium/*metabolism
;
Cyclic AMP/metabolism
;
Female
;
Guinea Pigs
;
Isoproterenol/*pharmacology
;
Male
;
Myocardial Contraction/*drug effects
;
Myocardium/metabolism
;
Phosphodiesterase Inhibitors/pharmacology
;
Sarcolemma/metabolism
;
Sarcoplasmic Reticulum/metabolism
;
Sodium/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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