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  • 1
    Electronic Resource
    Electronic Resource
    Separation of etoposide phosphate and methotrexate by capillary zone electrophoresis using UV detection with a high sensitivity cell (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 3022-3025 
    Details
    ISSN: 0173-0835
    Keywords: Capillary zone electrophoresis ; Etoposude phosphate ; Methotrexate ; Urine ; Plasma ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Etoposide phosphate and methotrexate are important anti-tumor chemotherapeutic agents. Our previously presented capillary zone electrophoresis (CZE) method using a high sensitivity cell (Z-cell) for quantitative analysis in biological media (urine, plasma) showed good precision and accuracy. The present results show that the investigation using a capillary with high sensitivity cell led to an approximately 10-fold improvement of the detection limit compared to standard capillaries. Plasma and urine samples were analyzed by using a calibration curve for drug concentrations between 0.1 and 100 μg/mL. Good detection limits and good relative standard deviations of the migration times and of the peak areas were observed in these experiments.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191638
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  • 2
    Electronic Resource
    Electronic Resource
    Two examples of rapid and simple drug analysis in pharmaceutical formulations using capillary electrophoresis: Naphazoline, dexamethasone and benzalkonium in nose drops and nystatin in an oily suspension (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 2907-2911 
    Details
    ISSN: 0173-0835
    Keywords: Capillary electrophoresis ; Naphazoline ; Dexamethasone ; Benzalkonium ; Nystatin ; Nonaqueous capillary electrophoresis ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Capillary electrophoresis is a versatile tool in pharmaceutical analysis. In the course of a revision of the “Standardrezepturen”, a German formula of standard dispensings for preparation in pharmacies, this technique has been applied to drug analysis in pharmaceutical formulations. The present paper deals with two different examples. First, naphazoline, dexamethasone and the preservative benzalkonium are quantified in nose drops without any sample preparation. Second, the antifungal antibiotic nystatin is quantified using nonaqueous capillary electrophoresis in methanol after sample preparation from an oily suspension.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191618
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of micelles by capillary electrophoresis (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 2145-2150 
    Details
    ISSN: 0173-0835
    Keywords: Micelles ; Bile salts ; Capillary electrophoresis ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A practical approach for the characterization of pure micelles, and binary or ternary mixed micelles by capillary electrophoretic methods is presented. Interest is focused on the determination of mobility and composition of the micelles. The investigations are performed with bile salts, phosphatidylcho-lines and fatty acids. Pure bile salt micelles are characterized with the help of marking and displacement methods. Binary bile salt/phospholipid and ternary bile salt/phospholipid/fatty acid micelles are analyzed using capillary electrophoresis (CE) techniques with standard and improved UV detection, laser-induced fluorescence and electrospray ionization - mass spectrometry (ESI-MS). For both the binary and the ternary systems, only one stable mixed micellar phase is found with a high negative mobility.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191218
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of partitioning behavior of cephalosporins using microemulsion and micellar electrokinetic chromatography (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 2895-2899 
    Details
    ISSN: 0173-0835
    Keywords: Cephalosporins ; Partition behavior ; Microemulsions ; Micellar electrokinetic chromatography ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Electrokinetic chromatography (EKC) was introduced to determine the partitioning behavior of various cephalosporins (cefpim, cefpirom, cefaloridin, cefaclor, cephalexin, cefuroxim, cefotaxim) in microemulsions (ME) and micellar (MC) systems. The partitioning behavior of cephalosporins in microemulsions was characterized calculating the capacity factor. The required parameters for the determination of the capacity factor (μaq and μme are the electrophoretic mobilities of the solutes in the aqueous phase and the microemulsion phase, μeff is the effective mobility in the microemulsion solution) were measured by EKC using cationic and anionic microemulsion systems consisting of the surfactants/n-heptane/1-butanol/10 mM phosphate buffer solution, pH 7.0. Electrokinetic chromatography was shown to be a useful method to quantify the partitioning behavior of drugs in oil/water microemulsion. The logarithm of the capacity factor was correlated with the logarithm of the 1-octanol/water partitioning coefficients.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191616
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