ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Biochemistry and Biotechnology  (4)
  • Chromosomes, Human, Pair 3/genetics  (1)
Collection
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Novel acrylamido monomers with higher hydrophilicity and improved hydrolytic stability: III. DNA separations by capillary electrophoresis in poly(N-acryloylaminopropanol) (1996)
    Weinheim : Wiley-Blackwell
    Electrophoresis 17 (1996), S. 738-743 
    Details
    ISSN: 0173-0835
    Keywords: N-Substituted acrylamides ; N-Acryloylaminopropanol ; Capillary electrophoresis ; DNA separations ; Liquid polymer ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Separation of DNA fragments in a novel polymer network, consisting of N-acryloylaminopropanol (AAP) is reported. The performance of this novel monomer, as a sieving liquid polymer in capillary zone electrophoresis, was evaluated. In 50 μm ID capillaries, an 8% solution of poly(AAP) can afford apex-resolution of the 123/124 bp adjacent pair of DNA fragments in marker V, typically unresolved in any poly(acrylamide) formulation. It is proposed that the distal -OH group in the AAP molecule can form transient H-bonds with the DNA double helix. Molecular modeling shows a meandering structure for poly(AAP), lacing the walls of half a cylinder, with kinks protruding at regular intervals, potentially able to fit into the major groove of DNA. Contrary to previously held beliefs, there seems to be a minimum length of the polymer for proper sieving of DNAs. For poly(acrylamides), a weight average molecular mass Mw 30 000 polymer offers no resolution, whereas a polymer of 250 000 to 400 000 Da exhibits optimum resolving power. For poly(AAP), the optimal length is in excess of 450 000 Da in Mw. Thus, it is shown that both the chemical composition of the monomer and the length of the polymer play a subtle, cooperative role in DNA separation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150170420
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Novel acrylamido monomers with higher hydrophilicity and improved hydrolytic stability: II. Properties of N-acryloylaminopropanol (1996)
    Weinheim : Wiley-Blackwell
    Electrophoresis 17 (1996), S. 732-737 
    Details
    ISSN: 0173-0835
    Keywords: N-Substituted acrylamides ; N-Acryloylaminopropanol ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The physico-chemical properties and the electrophoretic behavior of the novel set of monomers reported by (Simò-Alfonso et al. Electrophoresis 1996, 17, 723-731) have been evaluated. Of utmost importance was the combination of high hydrophilicity and extreme hydrolytic stability, most desired properties for any electrophoretic matrix, especially for protein fractionation. One of these monomers (N-acryloylaminopropanol, AAP) was found indeed to be extremely hydrophilic (with a partition coefficient P of only 0.10, vs. P = 0.13 for N-acryloylaminoethoxyethanol and P = 0.20 for acrylamide) and to possess excellent stability to alkaline hydrolysis. Its hydrolysis constant (0.008 L mol-1 min-1), as a free monomer, in an alkaline milieu, was found to be about one order of magnitude lower than conventional acrylamide (0.05 L mol-1 min-1). In the polymer state, the resistance to hydrolysis of poly(AAP) was assessed as 500 times greater than a conventional poly(acrylamide) matrix.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150170419
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Novel acrylamido monomers with higher hydrophilicity and improved hydrolytic stability: I. Synthetic route and product characterization (1996)
    Weinheim : Wiley-Blackwell
    Electrophoresis 17 (1996), S. 723-731 
    Details
    ISSN: 0173-0835
    Keywords: N-Substituted acrylamides ; N-Acryloylaminopropanol ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The novel acrylamido monomer reported by our group (N-acryloylaminoethoxyethanol, AAEE; Chiari et al., Electrophoresis 1994, 15, 177-186), found to combine high hydrophilicity with extraordinary resistance to alkaline hydrolysis, has come under closer scrutiny due to unexpected and random autopolymerization while stored as a 1/1 v/v water solution at 4°C (possibly due to a greater oxidability of the ether group). We have additionally found a unique degradation pathway of the monomer, called “1-6 H-transfer”, by which the C1 (on the double bond site), by constantly ramming against the C6, next to the ether oxygen (O7, which in fact favors the transfer of the hydrogen atom by C1), produces radicals which more efficiently add to the monomer favoring autopolymerization and cross-linking. A number of novel monomers is proposed while maintaining the other unique chracteristics of AAEE. One of them, N-acryloylaminopropanol, offers all the unique, special qualities of AAEE, without the noxious aspects of autopolymerization. Additionally, a synthetic route was optimized, yielding an essentially pure product in a single reaction step, with a yield 〉99% and an equivalent purity (〉99%). The synthesis consists in reacting acryloyl chloride at -40°C in presence of a twofold molar excess of aminopropanol and in ethanol (instead of methanol) as solvent. Other solvents, as well as the use of triethylamine for neutralizing the HCl produced, were found to give a variety of undesired byproducts.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150170418
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Surface modification based on Si-O and Si-C sublayers and a series of N-substituted acrylamide top-layers for capillary electrophoresis (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 1677-1682 
    Details
    ISSN: 0173-0835
    Keywords: Coating ; Electroosmosis ; Silica ; Capillary electrophoresis ; N-substituted acrylamide ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Two approaches were used to prepare a series of surface-modified capillaries. In the first, a sublayer was formed by coupling γ-methacryloxypropyltrimeth-oxysilane to the surface silanol groups forming an SI-O bond; a top layer was then formed by polymerizing acrylamide in the capillary, which reacted with the sublayer. In the second approach, a sublayer was formed by silanol chlorination, followed by Grignard coupling of vinylmagnesium bromide to form an Si-C bond at the surface; a top layer was formed by polymerizing either acrylamide (AA), dimethylacrylamide (DMA), N-acryloylaminoethoxyethanol (AAEE), or N-acryloylaminopropanol (AAP) onto the sublayer. The Si-C-poly(AA) capillaries were more stable and produced an approximately 10-fold lower electroosmotic flow compared to the Si-O-poly(AA) capillaries. The Si-C sublayer was used to compare the performance of all four top layers. Electroosmotic flow decreased in the order: Si-O-poly(AA), Si-C-poly(AA), Si-C-poly(AAEE), Si-C-poly(DMA), and Si-C-poly(AAP). Si-C-poly(AA) showed evidence of irreversible degradation at pH 9 already after 40-50 runs. Si-C-polyAAP-coated capillaries demonstrated superior efficiency and migration time reproducibility for a number of alkaline proteins and for fluorescently labeled ovalbumin. Excellent performance was maintained, in the case of poly(AAP), for a least 300 runs (of 30 min duration) at pH 9.0.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191026
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    facet.materialart.
    Unknown
    Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-10-01
    Description: Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P 〈 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955183/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955183/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lango Allen, Hana -- Estrada, Karol -- Lettre, Guillaume -- Berndt, Sonja I -- Weedon, Michael N -- Rivadeneira, Fernando -- Willer, Cristen J -- Jackson, Anne U -- Vedantam, Sailaja -- Raychaudhuri, Soumya -- Ferreira, Teresa -- Wood, Andrew R -- Weyant, Robert J -- Segre, Ayellet V -- Speliotes, Elizabeth K -- Wheeler, Eleanor -- Soranzo, Nicole -- Park, Ju-Hyun -- Yang, Jian -- Gudbjartsson, Daniel -- Heard-Costa, Nancy L -- Randall, Joshua C -- Qi, Lu -- Vernon Smith, Albert -- Magi, Reedik -- Pastinen, Tomi -- Liang, Liming -- Heid, Iris M -- Luan, Jian'an -- Thorleifsson, Gudmar -- Winkler, Thomas W -- Goddard, Michael E -- Sin Lo, Ken -- Palmer, Cameron -- Workalemahu, Tsegaselassie -- Aulchenko, Yurii S -- Johansson, Asa -- Zillikens, M Carola -- Feitosa, Mary F -- Esko, Tonu -- Johnson, Toby -- Ketkar, Shamika -- Kraft, Peter -- Mangino, Massimo -- Prokopenko, Inga -- Absher, Devin -- Albrecht, Eva -- Ernst, Florian -- Glazer, Nicole L -- Hayward, Caroline -- Hottenga, Jouke-Jan -- Jacobs, Kevin B -- Knowles, Joshua W -- Kutalik, Zoltan -- Monda, Keri L -- Polasek, Ozren -- Preuss, Michael -- Rayner, Nigel W -- Robertson, Neil R -- Steinthorsdottir, Valgerdur -- Tyrer, Jonathan P -- Voight, Benjamin F -- Wiklund, Fredrik -- Xu, Jianfeng -- Zhao, Jing Hua -- Nyholt, Dale R -- Pellikka, Niina -- Perola, Markus -- Perry, John R B -- Surakka, Ida -- Tammesoo, Mari-Liis -- Altmaier, Elizabeth L -- Amin, Najaf -- Aspelund, Thor -- Bhangale, Tushar -- Boucher, Gabrielle -- Chasman, Daniel I -- Chen, Constance -- Coin, Lachlan -- Cooper, Matthew N -- Dixon, Anna L -- Gibson, Quince -- Grundberg, Elin -- Hao, Ke -- Juhani Junttila, M -- Kaplan, Lee M -- Kettunen, Johannes -- Konig, Inke R -- Kwan, Tony -- Lawrence, Robert W -- Levinson, Douglas F -- Lorentzon, Mattias -- McKnight, Barbara -- Morris, Andrew P -- Muller, Martina -- Suh Ngwa, Julius -- Purcell, Shaun -- Rafelt, Suzanne -- Salem, Rany M -- Salvi, Erika -- Sanna, Serena -- Shi, Jianxin -- Sovio, Ulla -- Thompson, John R -- Turchin, Michael C -- Vandenput, Liesbeth -- Verlaan, Dominique J -- Vitart, Veronique -- White, Charles C -- Ziegler, Andreas -- Almgren, Peter -- Balmforth, Anthony J -- Campbell, Harry -- Citterio, Lorena -- De Grandi, Alessandro -- Dominiczak, Anna -- Duan, Jubao -- Elliott, Paul -- Elosua, Roberto -- Eriksson, Johan G -- Freimer, Nelson B -- Geus, Eco J C -- Glorioso, Nicola -- Haiqing, Shen -- Hartikainen, Anna-Liisa -- Havulinna, Aki S -- Hicks, Andrew A -- Hui, Jennie -- Igl, Wilmar -- Illig, Thomas -- Jula, Antti -- Kajantie, Eero -- Kilpelainen, Tuomas O -- Koiranen, Markku -- Kolcic, Ivana -- Koskinen, Seppo -- Kovacs, Peter -- Laitinen, Jaana -- Liu, Jianjun -- Lokki, Marja-Liisa -- Marusic, Ana -- Maschio, Andrea -- Meitinger, Thomas -- Mulas, Antonella -- Pare, Guillaume -- Parker, Alex N -- Peden, John F -- Petersmann, Astrid -- Pichler, Irene -- Pietilainen, Kirsi H -- Pouta, Anneli -- Ridderstrale, Martin -- Rotter, Jerome I -- Sambrook, Jennifer G -- Sanders, Alan R -- Schmidt, Carsten Oliver -- Sinisalo, Juha -- Smit, Jan H -- Stringham, Heather M -- Bragi Walters, G -- Widen, Elisabeth -- Wild, Sarah H -- Willemsen, Gonneke -- Zagato, Laura -- Zgaga, Lina -- Zitting, Paavo -- Alavere, Helene -- Farrall, Martin -- McArdle, Wendy L -- Nelis, Mari -- Peters, Marjolein J -- Ripatti, Samuli -- van Meurs, Joyce B J -- Aben, Katja K -- Ardlie, Kristin G -- Beckmann, Jacques S -- Beilby, John P -- Bergman, Richard N -- Bergmann, Sven -- Collins, Francis S -- Cusi, Daniele -- den Heijer, Martin -- Eiriksdottir, Gudny -- Gejman, Pablo V -- Hall, Alistair S -- Hamsten, Anders -- Huikuri, Heikki V -- Iribarren, Carlos -- Kahonen, Mika -- Kaprio, Jaakko -- Kathiresan, Sekar -- Kiemeney, Lambertus -- Kocher, Thomas -- Launer, Lenore J -- Lehtimaki, Terho -- Melander, Olle -- Mosley, Tom H Jr -- Musk, Arthur W -- Nieminen, Markku S -- O'Donnell, Christopher J -- Ohlsson, Claes -- Oostra, Ben -- Palmer, Lyle J -- Raitakari, Olli -- Ridker, Paul M -- Rioux, John D -- Rissanen, Aila -- Rivolta, Carlo -- Schunkert, Heribert -- Shuldiner, Alan R -- Siscovick, David S -- Stumvoll, Michael -- Tonjes, Anke -- Tuomilehto, Jaakko -- van Ommen, Gert-Jan -- Viikari, Jorma -- Heath, Andrew C -- Martin, Nicholas G -- Montgomery, Grant W -- Province, Michael A -- Kayser, Manfred -- Arnold, Alice M -- Atwood, Larry D -- Boerwinkle, Eric -- Chanock, Stephen J -- Deloukas, Panos -- Gieger, Christian -- Gronberg, Henrik -- Hall, Per -- Hattersley, Andrew T -- Hengstenberg, Christian -- Hoffman, Wolfgang -- Lathrop, G Mark -- Salomaa, Veikko -- Schreiber, Stefan -- Uda, Manuela -- Waterworth, Dawn -- Wright, Alan F -- Assimes, Themistocles L -- Barroso, Ines -- Hofman, Albert -- Mohlke, Karen L -- Boomsma, Dorret I -- Caulfield, Mark J -- Cupples, L Adrienne -- Erdmann, Jeanette -- Fox, Caroline S -- Gudnason, Vilmundur -- Gyllensten, Ulf -- Harris, Tamara B -- Hayes, Richard B -- Jarvelin, Marjo-Riitta -- Mooser, Vincent -- Munroe, Patricia B -- Ouwehand, Willem H -- Penninx, Brenda W -- Pramstaller, Peter P -- Quertermous, Thomas -- Rudan, Igor -- Samani, Nilesh J -- Spector, Timothy D -- Volzke, Henry -- Watkins, Hugh -- Wilson, James F -- Groop, Leif C -- Haritunians, Talin -- Hu, Frank B -- Kaplan, Robert C -- Metspalu, Andres -- North, Kari E -- Schlessinger, David -- Wareham, Nicholas J -- Hunter, David J -- O'Connell, Jeffrey R -- Strachan, David P -- Wichmann, H-Erich -- Borecki, Ingrid B -- van Duijn, Cornelia M -- Schadt, Eric E -- Thorsteinsdottir, Unnur -- Peltonen, Leena -- Uitterlinden, Andre G -- Visscher, Peter M -- Chatterjee, Nilanjan -- Loos, Ruth J F -- Boehnke, Michael -- McCarthy, Mark I -- Ingelsson, Erik -- Lindgren, Cecilia M -- Abecasis, Goncalo R -- Stefansson, Kari -- Frayling, Timothy M -- Hirschhorn, Joel N -- 064890/Wellcome Trust/United Kingdom -- 068545/Wellcome Trust/United Kingdom -- 068545/Z/02/Wellcome Trust/United Kingdom -- 072856/Wellcome Trust/United Kingdom -- 072960/Wellcome Trust/United Kingdom -- 075491/Wellcome Trust/United Kingdom -- 076113/Wellcome Trust/United Kingdom -- 076113/B/04/Z/Wellcome Trust/United Kingdom -- 076113/C/04/Z/Wellcome Trust/United Kingdom -- 077016/Wellcome Trust/United Kingdom -- 077016/Z/05/Z/Wellcome Trust/United Kingdom -- 079557/Wellcome Trust/United Kingdom -- 079771/Wellcome Trust/United Kingdom -- 079895/Wellcome Trust/United Kingdom -- 081682/Wellcome Trust/United Kingdom -- 081682/Z/06/Z/Wellcome Trust/United Kingdom -- 083270/Wellcome Trust/United Kingdom -- 084183/Z/07/Z/Wellcome Trust/United Kingdom -- 085301/Wellcome Trust/United Kingdom -- 085301/Z/08/Z/Wellcome Trust/United Kingdom -- 086596/Wellcome Trust/United Kingdom -- 086596/Z/08/Z/Wellcome Trust/United Kingdom -- 088885/Wellcome Trust/United Kingdom -- 090532/Wellcome Trust/United Kingdom -- 091746/Wellcome Trust/United Kingdom -- 091746/Z/10/Z/Wellcome Trust/United Kingdom -- 263-MA-410953/PHS HHS/ -- AA014041/AA/NIAAA NIH HHS/ -- AA07535/AA/NIAAA NIH HHS/ -- AA10248/AA/NIAAA NIH HHS/ -- AA13320/AA/NIAAA NIH HHS/ -- AA13321/AA/NIAAA NIH HHS/ -- AA13326/AA/NIAAA NIH HHS/ -- CA047988/CA/NCI NIH HHS/ -- CA49449/CA/NCI NIH HHS/ -- CA50385/CA/NCI NIH HHS/ -- CA65725/CA/NCI NIH HHS/ -- CA67262/CA/NCI NIH HHS/ -- CA87969/CA/NCI NIH HHS/ -- CZB/4/276/Chief Scientist Office/United Kingdom -- CZB/4/279/Chief Scientist Office/United Kingdom -- CZB/4/710/Chief Scientist Office/United Kingdom -- DA12854/DA/NIDA NIH HHS/ -- DK062370/DK/NIDDK NIH HHS/ -- DK063491/DK/NIDDK NIH HHS/ -- DK072193/DK/NIDDK NIH HHS/ -- DK079466/DK/NIDDK NIH HHS/ -- DK080145/DK/NIDDK NIH HHS/ -- DK46200/DK/NIDDK NIH HHS/ -- DK58845/DK/NIDDK NIH HHS/ -- F32 DK079466/DK/NIDDK NIH HHS/ -- F32 DK079466-01/DK/NIDDK NIH HHS/ -- G0000649/Medical Research Council/United Kingdom -- G0000934/Medical Research Council/United Kingdom -- G0500539/Medical Research Council/United Kingdom -- G0600331/Medical Research Council/United Kingdom -- G0600331(77796)/Medical Research Council/United Kingdom -- G0601261/Medical Research Council/United Kingdom -- G0701863/Medical Research Council/United Kingdom -- G9521010/Medical Research Council/United Kingdom -- G9521010(63660)/Medical Research Council/United Kingdom -- G9521010D/Medical Research Council/United Kingdom -- HG002651/HG/NHGRI NIH HHS/ -- HG005214/HG/NHGRI NIH HHS/ -- HG005581/HG/NHGRI NIH HHS/ -- HHSN268200625226C/PHS HHS/ -- HL043851/HL/NHLBI NIH HHS/ -- HL084729/HL/NHLBI NIH HHS/ -- HL69757/HL/NHLBI NIH HHS/ -- HL71981/HL/NHLBI NIH HHS/ -- K05 AA017688/AA/NIAAA NIH HHS/ -- K08 AR055688/AR/NIAMS NIH HHS/ -- K08 AR055688-03/AR/NIAMS NIH HHS/ -- K08 AR055688-04/AR/NIAMS NIH HHS/ -- K08-AR055688/AR/NIAMS NIH HHS/ -- K23 DK080145/DK/NIDDK NIH HHS/ -- K23 DK080145-01/DK/NIDDK NIH HHS/ -- K23-DK080145/DK/NIDDK NIH HHS/ -- K99-HL094535/HL/NHLBI NIH HHS/ -- M01-RR00425/RR/NCRR NIH HHS/ -- MC_QA137934/Medical Research Council/United Kingdom -- MC_U106179471/Medical Research Council/United Kingdom -- MC_U106188470/Medical Research Council/United Kingdom -- MC_U127561128/Medical Research Council/United Kingdom -- MH084698/MH/NIMH NIH HHS/ -- N01-AG12100/AG/NIA NIH HHS/ -- N01-AG12109/AG/NIA NIH HHS/ -- N01-G65403/PHS HHS/ -- N01-HC15103/HC/NHLBI NIH HHS/ -- N01-HC25195/HC/NHLBI NIH HHS/ -- N01-HC35129/HC/NHLBI NIH HHS/ -- N01-HC45133/HC/NHLBI NIH HHS/ -- N01-HC55015/HC/NHLBI NIH HHS/ -- N01-HC55016/HC/NHLBI NIH HHS/ -- N01-HC55018/HC/NHLBI NIH HHS/ -- N01-HC55019/HC/NHLBI NIH HHS/ -- N01-HC55020/HC/NHLBI NIH HHS/ -- N01-HC55021/HC/NHLBI NIH HHS/ -- N01-HC55022/HC/NHLBI NIH HHS/ -- N01-HC55222/HC/NHLBI NIH HHS/ -- N01-HC75150/HC/NHLBI NIH HHS/ -- N01-HC85079/HC/NHLBI NIH HHS/ -- N01-HC85080/HC/NHLBI NIH HHS/ -- N01-HC85081/HC/NHLBI NIH HHS/ -- N01-HC85082/HC/NHLBI NIH HHS/ -- N01-HC85083/HC/NHLBI NIH HHS/ -- N01-HC85084/HC/NHLBI NIH HHS/ -- N01-HC85085/HC/NHLBI NIH HHS/ -- N01-HC85086/HC/NHLBI NIH HHS/ -- N02-HL-6-4278/HL/NHLBI NIH HHS/ -- P01 CA087969/CA/NCI NIH HHS/ -- P01 CA087969-12/CA/NCI NIH HHS/ -- P30 DK072488/DK/NIDDK NIH HHS/ -- PG/02/128/British Heart Foundation/United Kingdom -- PG/02/128/14470/British Heart Foundation/United Kingdom -- R01 AA007535/AA/NIAAA NIH HHS/ -- R01 AA007535-08/AA/NIAAA NIH HHS/ -- R01 AA013320-04/AA/NIAAA NIH HHS/ -- R01 AA013321/AA/NIAAA NIH HHS/ -- R01 AA013321-05/AA/NIAAA NIH HHS/ -- R01 AA013326-05/AA/NIAAA NIH HHS/ -- R01 AA014041-05/AA/NIAAA NIH HHS/ -- R01 AG031890/AG/NIA NIH HHS/ -- R01 AG031890-02/AG/NIA NIH HHS/ -- R01 CA047988/CA/NCI NIH HHS/ -- R01 CA047988-20/CA/NCI NIH HHS/ -- R01 CA050385/CA/NCI NIH HHS/ -- R01 CA050385-20/CA/NCI NIH HHS/ -- R01 CA065725/CA/NCI NIH HHS/ -- R01 CA065725-14/CA/NCI NIH HHS/ -- R01 CA067262/CA/NCI NIH HHS/ -- R01 CA067262-14/CA/NCI NIH HHS/ -- R01 CA104021/CA/NCI NIH HHS/ -- R01 CA104021-02/CA/NCI NIH HHS/ -- R01 DA012854/DA/NIDA NIH HHS/ -- R01 DA012854-09/DA/NIDA NIH HHS/ -- R01 DK058845/DK/NIDDK NIH HHS/ -- R01 DK058845-11/DK/NIDDK NIH HHS/ -- R01 DK068336/DK/NIDDK NIH HHS/ -- R01 DK068336-01/DK/NIDDK NIH HHS/ -- R01 DK072193/DK/NIDDK NIH HHS/ -- R01 DK072193-05/DK/NIDDK NIH HHS/ -- R01 DK073490/DK/NIDDK NIH HHS/ -- R01 DK073490-01/DK/NIDDK NIH HHS/ -- R01 DK075681/DK/NIDDK NIH HHS/ -- R01 DK075681-02/DK/NIDDK NIH HHS/ -- R01 DK075787/DK/NIDDK NIH HHS/ -- R01 DK075787-03/DK/NIDDK NIH HHS/ -- R01 DK089256/DK/NIDDK NIH HHS/ -- R01 DK091718/DK/NIDDK NIH HHS/ -- R01 HG002651/HG/NHGRI NIH HHS/ -- R01 HG002651-05/HG/NHGRI NIH HHS/ -- R01 HL043851/HL/NHLBI NIH HHS/ -- R01 HL043851-10/HL/NHLBI NIH HHS/ -- R01 HL059367/HL/NHLBI NIH HHS/ -- R01 HL059367-10/HL/NHLBI NIH HHS/ -- R01 HL071981/HL/NHLBI NIH HHS/ -- R01 HL071981-07/HL/NHLBI NIH HHS/ -- R01 HL086694/HL/NHLBI NIH HHS/ -- R01 HL086694-02/HL/NHLBI NIH HHS/ -- R01 HL087641/HL/NHLBI NIH HHS/ -- R01 HL087641-01/HL/NHLBI NIH HHS/ -- R01 HL087647/HL/NHLBI NIH HHS/ -- R01 HL087647-01/HL/NHLBI NIH HHS/ -- R01 HL087652/HL/NHLBI NIH HHS/ -- R01 HL087652-01/HL/NHLBI NIH HHS/ -- R01 HL087676/HL/NHLBI NIH HHS/ -- R01 HL087676-01/HL/NHLBI NIH HHS/ -- R01 HL087679-01/HL/NHLBI NIH HHS/ -- R01 HL087700/HL/NHLBI NIH HHS/ -- R01 HL087700-03/HL/NHLBI NIH HHS/ -- R01 HL088119/HL/NHLBI NIH HHS/ -- R01 HL088119-01/HL/NHLBI NIH HHS/ -- R01 HL117078/HL/NHLBI NIH HHS/ -- R01 MH059160/MH/NIMH NIH HHS/ -- R01 MH059160-04/MH/NIMH NIH HHS/ -- R01 MH059565/MH/NIMH NIH HHS/ -- R01 MH059565-06/MH/NIMH NIH HHS/ -- R01 MH059566/MH/NIMH NIH HHS/ -- R01 MH059566-08/MH/NIMH NIH HHS/ -- R01 MH059571/MH/NIMH NIH HHS/ -- R01 MH059571-05/MH/NIMH NIH HHS/ -- R01 MH059586/MH/NIMH NIH HHS/ -- R01 MH059586-08/MH/NIMH NIH HHS/ -- R01 MH059587-09/MH/NIMH NIH HHS/ -- R01 MH059588-08/MH/NIMH NIH HHS/ -- R01 MH060870-09/MH/NIMH NIH HHS/ -- R01 MH060879/MH/NIMH NIH HHS/ -- R01 MH060879-08/MH/NIMH NIH HHS/ -- R01 MH061675/MH/NIMH NIH HHS/ -- R01 MH061675-09/MH/NIMH NIH HHS/ -- R01 MH067257-04/MH/NIMH NIH HHS/ -- R01 MH081800/MH/NIMH NIH HHS/ -- R01 MH081800-01/MH/NIMH NIH HHS/ -- R01-AG031890/AG/NIA NIH HHS/ -- R01-DK068336/DK/NIDDK NIH HHS/ -- R01-DK073490/DK/NIDDK NIH HHS/ -- R01-DK075681/DK/NIDDK NIH HHS/ -- R01-DK075787/DK/NIDDK NIH HHS/ -- R01-HL086694/HL/NHLBI NIH HHS/ -- R01-HL087641/HL/NHLBI NIH HHS/ -- R01-HL087647/HL/NHLBI NIH HHS/ -- R01-HL087652/HL/NHLBI NIH HHS/ -- R01-HL087676/HL/NHLBI NIH HHS/ -- R01-HL087679/HL/NHLBI NIH HHS/ -- R01-HL087700/HL/NHLBI NIH HHS/ -- R01-HL088119/HL/NHLBI NIH HHS/ -- R01-HL59367/HL/NHLBI NIH HHS/ -- R01-MH059160/MH/NIMH NIH HHS/ -- R01-MH59565/MH/NIMH NIH HHS/ -- R01-MH59566/MH/NIMH NIH HHS/ -- R01-MH59571/MH/NIMH NIH HHS/ -- R01-MH59586/MH/NIMH NIH HHS/ -- R01-MH59587/MH/NIMH NIH HHS/ -- R01-MH59588/MH/NIMH NIH HHS/ -- R01-MH60870/MH/NIMH NIH HHS/ -- R01-MH60879/MH/NIMH NIH HHS/ -- R01-MH61675/MH/NIMH NIH HHS/ -- R01-MH63706/MH/NIMH NIH HHS/ -- R01-MH67257/MH/NIMH NIH HHS/ -- R01-MH79469/MH/NIMH NIH HHS/ -- R01-MH81800/MH/NIMH NIH HHS/ -- RC2 HG005581/HG/NHGRI NIH HHS/ -- RC2 HG005581-02/HG/NHGRI NIH HHS/ -- RL1 MH083268/MH/NIMH NIH HHS/ -- RL1 MH083268-05/MH/NIMH NIH HHS/ -- RL1-MH083268/MH/NIMH NIH HHS/ -- T32-HG00040/HG/NHGRI NIH HHS/ -- U01 CA049449/CA/NCI NIH HHS/ -- U01 CA049449-21/CA/NCI NIH HHS/ -- U01 CA098233/CA/NCI NIH HHS/ -- U01 CA098233-08/CA/NCI NIH HHS/ -- U01 DK062370/DK/NIDDK NIH HHS/ -- U01 DK062370-08/DK/NIDDK NIH HHS/ -- U01 DK062418/DK/NIDDK NIH HHS/ -- U01 GM074518/GM/NIGMS NIH HHS/ -- U01 GM074518-05/GM/NIGMS NIH HHS/ -- U01 HG004399/HG/NHGRI NIH HHS/ -- U01 HG004399-02/HG/NHGRI NIH HHS/ -- U01 HG004402/HG/NHGRI NIH HHS/ -- U01 HG004402-02/HG/NHGRI NIH HHS/ -- U01 HG005214/HG/NHGRI NIH HHS/ -- U01 HG005214-02/HG/NHGRI NIH HHS/ -- U01 HL069757/HL/NHLBI NIH HHS/ -- U01 HL069757-10/HL/NHLBI NIH HHS/ -- U01 HL072515/HL/NHLBI NIH HHS/ -- U01 HL072515-06/HL/NHLBI NIH HHS/ -- U01 HL080295/HL/NHLBI NIH HHS/ -- U01 HL080295-04/HL/NHLBI NIH HHS/ -- U01 HL084729/HL/NHLBI NIH HHS/ -- U01 HL084729-03/HL/NHLBI NIH HHS/ -- U01 HL084756/HL/NHLBI NIH HHS/ -- U01 HL084756-03/HL/NHLBI NIH HHS/ -- U01 MH079469/MH/NIMH NIH HHS/ -- U01 MH079469-03/MH/NIMH NIH HHS/ -- U01 MH079470/MH/NIMH NIH HHS/ -- U01 MH079470-03/MH/NIMH NIH HHS/ -- U01-CA098233/CA/NCI NIH HHS/ -- U01-GM074518/GM/NIGMS NIH HHS/ -- U01-HG004399/HG/NHGRI NIH HHS/ -- U01-HG004402/HG/NHGRI NIH HHS/ -- U01-HL080295/HL/NHLBI NIH HHS/ -- U01-HL084756/HL/NHLBI NIH HHS/ -- U01-HL72515/HL/NHLBI NIH HHS/ -- U01-MH79469/MH/NIMH NIH HHS/ -- U01-MH79470/MH/NIMH NIH HHS/ -- U54-RR020278/RR/NCRR NIH HHS/ -- UL1-RR025005/RR/NCRR NIH HHS/ -- Z01-AG00675/AG/NIA NIH HHS/ -- Z01-AG007380/AG/NIA NIH HHS/ -- Z01-HG000024/HG/NHGRI NIH HHS/ -- Cancer Research UK/United Kingdom -- Intramural NIH HHS/ -- England -- Nature. 2010 Oct 14;467(7317):832-8. doi: 10.1038/nature09410. Epub 2010 Sep 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20881960" target="_blank"〉PubMed〈/a〉
    Keywords: Body Height/*genetics ; Chromosomes, Human, Pair 3/genetics ; Genetic Loci/*genetics ; Genetic Predisposition to Disease/genetics ; Genome, Human/*genetics ; Genome-Wide Association Study ; Humans ; Metabolic Networks and Pathways/*genetics ; Multifactorial Inheritance/genetics ; Phenotype ; Polymorphism, Single Nucleotide/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...