ISSN:
0006-3592
Keywords:
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The optimum operating temperature and pH have been determined for a catalyst prepared by the insolubilization of a hepatic microsomal mixed-function oxidase on glass beads. Temperature is a more significant variable than pH in determining potential catalyst yield (total product/unit catalyst). An operating range of about 25-28°C is optimal with respect to catalyst life at pH 7.6. Like the purified soluble oxidase, the glass bead-mounted enzyme catalyzes the NADPH- and oxygen-dependent oxidation of a variety of amines, hydrazines, and thioureylenes. The catalyst has been used in a simple slurry reactor to prepare mg quantities of N-oxide metabolites of prochlorperazine, guanethidine, and ethylmorphine.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bit.260170109
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