ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Probing neutralino properties in minimal supergravity with bilinear R-parity violation (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-10-02
    Description: Author(s): F. de Campos, O. J. P. Éboli, M. B. Magro, W. Porod, D. Restrepo, S. P. Das, M. Hirsch, and J. W. F. Valle Supersymmetric models with bilinear R -parity violation can account for the observed neutrino masses and mixing parameters indicated by neutrino oscillation data. We consider minimal supergravity versions of bilinear R -parity violation where the lightest supersymmetric particle is a neutralino. This ... [Phys. Rev. D 86, 075001] Published Mon Oct 01, 2012
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    AIDS vaccine development (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agosto, M -- Allan, J -- Benson, C -- Berger, E A -- Blumenthal, R -- Burton, D -- Clements, J -- Coffin, J -- Connor, R -- Cullen, B -- Desrosiers, R -- Dimitrov, D -- Doms, R -- Emerman, M -- Feinberg, M -- Fultz, P -- Gerard, C -- Gonsalves, G -- Haase, A -- Haigwood, N -- Hirsch, V -- Ho, D -- Hoxie, J A -- Hu, S L -- Zingale, D -- New York, N.Y. -- Science. 1998 May 8;280(5365):803, 804-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9599148" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/immunology ; Acquired Immunodeficiency Syndrome/prevention & control ; *Clinical Trials as Topic ; HIV Envelope Protein gp120/immunology ; HIV-1/immunology ; Humans ; National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-04-01
    Description: Characterization of the host immune response to human immunodeficiency virus type 1 (HIV-1) is critical to the rational design of an effective AIDS vaccine. In this study, cytotoxic T lymphocytes (CTL) specific for HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) were found in blood samples from HIV-1-infected individuals. CTL targets were prepared by immortalizing B cells from ten seropositive and six seronegative individuals, and then infecting these cells with recombinant vaccinia viruses containing HIV-1 genes. CTL directed against autologous B lymphoblasts expressing HIV-1 reverse transcriptase were detected in fresh blood samples from eight HIV-1 seropositive subjects, but in no seronegative controls. The effector cells were identified as major histocompatibility complex-restricted CD3+CD8+ lymphocytes. Because the HIV-1 pol gene is highly conserved among different isolates and generates both humoral and cellular immune responses, it bears consideration for inclusion in a candidate AIDS vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, B D -- Flexner, C -- Paradis, T J -- Fuller, T C -- Hirsch, M S -- Schooley, R T -- Moss, B -- CA37461/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 1;240(4848):64-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2451288" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; DNA, Recombinant ; Genes, Viral ; HIV/*enzymology/genetics ; HIV Seropositivity ; HLA Antigens/immunology ; Humans ; RNA-Directed DNA Polymerase/*immunology ; T-Lymphocytes, Cytotoxic/*immunology ; Vaccinia virus/genetics/immunology ; Viral Vaccines/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    $\mathrm{Δ}L≥4$ lepton number violating processes (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-07-27
    Description: Author(s): Renato M. Fonseca and Martin Hirsch We discuss the experimental prospects for observing processes which violate lepton number ( Δ L ) in four units (or more). First, we reconsider neutrinoless quadruple beta decay, deriving a model independent and very conservative lower limit on its half-life of the order of 10 41     ys for Nd 150 . This ren... [Phys. Rev. D 98, 015035] Published Thu Jul 26, 2018
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Neutrinoless double beta decay and QCD running at low energy scales (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-06-06
    Description: Author(s): M. González, M. Hirsch, and S. G. Kovalenko There is a common belief that the main uncertainties in the theoretical analysis of neutrinoless double beta ( 0 ν β β ) decay originate from the nuclear matrix elements. Here, we uncover another previously overlooked source of potentially large uncertainties stemming from nonperturbative QCD effects. Re... [Phys. Rev. D 97, 115005] Published Tue Jun 05, 2018
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    The ubiquitylation machinery of the endoplasmic reticulum (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-03-28
    Description: As proteins travel through the endoplasmic reticulum (ER), a quality-control system retains newly synthesized polypeptides and supports their maturation. Only properly folded proteins are released to their designated destinations. Proteins that cannot mature are left to accumulate, impairing the function of the ER. To maintain homeostasis, the protein-quality-control system singles out aberrant polypeptides and delivers them to the cytosol, where they are destroyed by the proteasome. The importance of this pathway is evident from the growing list of pathologies associated with quality-control defects in the ER.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirsch, Christian -- Gauss, Robert -- Horn, Sabine C -- Neuber, Oliver -- Sommer, Thomas -- England -- Nature. 2009 Mar 26;458(7237):453-60. doi: 10.1038/nature07962.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Delbruck Center for Molecular Medicine, Robert-Rossle-Strasse 10, 13125 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19325625" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Endoplasmic Reticulum/chemistry/*metabolism ; Homeostasis ; Humans ; Intracellular Membranes/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Folding ; Protein Processing, Post-Translational ; Proteins/*chemistry/*metabolism ; *Ubiquitination
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-05-12
    Description: An extensive repertoire of modifications is known to underlie the versatile coding, structural and catalytic functions of RNA, but it remains largely uncharted territory. Although biochemical studies indicate that N(6)-methyladenosine (m(6)A) is the most prevalent internal modification in messenger RNA, an in-depth study of its distribution and functions has been impeded by a lack of robust analytical methods. Here we present the human and mouse m(6)A modification landscape in a transcriptome-wide manner, using a novel approach, m(6)A-seq, based on antibody-mediated capture and massively parallel sequencing. We identify over 12,000 m(6)A sites characterized by a typical consensus in the transcripts of more than 7,000 human genes. Sites preferentially appear in two distinct landmarks--around stop codons and within long internal exons--and are highly conserved between human and mouse. Although most sites are well preserved across normal and cancerous tissues and in response to various stimuli, a subset of stimulus-dependent, dynamically modulated sites is identified. Silencing the m(6)A methyltransferase significantly affects gene expression and alternative splicing patterns, resulting in modulation of the p53 (also known as TP53) signalling pathway and apoptosis. Our findings therefore suggest that RNA decoration by m(6)A has a fundamental role in regulation of gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dominissini, Dan -- Moshitch-Moshkovitz, Sharon -- Schwartz, Schraga -- Salmon-Divon, Mali -- Ungar, Lior -- Osenberg, Sivan -- Cesarkas, Karen -- Jacob-Hirsch, Jasmine -- Amariglio, Ninette -- Kupiec, Martin -- Sorek, Rotem -- Rechavi, Gideon -- England -- Nature. 2012 Apr 29;485(7397):201-6. doi: 10.1038/nature11112.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22575960" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*analogs & derivatives/*genetics ; Alternative Splicing ; Animals ; Base Sequence ; Cell Line, Tumor ; Conserved Sequence ; Evolution, Molecular ; Hep G2 Cells ; Humans ; *Metabolome/genetics ; Methylation ; Methyltransferases/deficiency/genetics/metabolism ; Mice ; RNA/genetics/*metabolism ; RNA, Ribosomal/genetics/metabolism ; RNA, Transfer/genetics/metabolism ; RNA-Binding Proteins/metabolism ; Transcriptome/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-07-05
    Description: Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to membrane traffic. Among the seven eukaryotic phosphoinositides the best studied species is phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), which is concentrated at the plasma membrane where, among other functions, it is required for the nucleation of endocytic clathrin-coated pits. No phosphatidylinositol other than PI(4,5)P2 has been implicated in clathrin-mediated endocytosis, whereas the subsequent endosomal stages of the endocytic pathway are dominated by phosphatidylinositol-3-phosphates(PI(3)P). How phosphatidylinositol conversion from PI(4,5)P2-positive endocytic intermediates to PI(3)P-containing endosomes is achieved is unclear. Here we show that formation of phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) by class II phosphatidylinositol-3-kinase C2alpha (PI(3)K C2alpha) spatiotemporally controls clathrin-mediated endocytosis. Depletion of PI(3,4)P2 or PI(3)K C2alpha impairs the maturation of late-stage clathrin-coated pits before fission. Timed formation of PI(3,4)P2 by PI(3)K C2alpha is required for selective enrichment of the BAR domain protein SNX9 at late-stage endocytic intermediates. These findings provide a mechanistic framework for the role of PI(3,4)P2 in endocytosis and unravel a novel discrete function of PI(3,4)P2 in a central cell physiological process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Posor, York -- Eichhorn-Gruenig, Marielle -- Puchkov, Dmytro -- Schoneberg, Johannes -- Ullrich, Alexander -- Lampe, Andre -- Muller, Rainer -- Zarbakhsh, Sirus -- Gulluni, Federico -- Hirsch, Emilio -- Krauss, Michael -- Schultz, Carsten -- Schmoranzer, Jan -- Noe, Frank -- Haucke, Volker -- England -- Nature. 2013 Jul 11;499(7457):233-7. doi: 10.1038/nature12360. Epub 2013 Jul 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Leibniz Institut fur Molekulare Pharmakologie & Freie Universitat Berlin, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23823722" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; COS Cells ; Cercopithecus aethiops ; Class II Phosphatidylinositol 3-Kinases/metabolism ; Clathrin-Coated Vesicles/metabolism ; *Endocytosis ; HEK293 Cells ; HeLa Cells ; Humans ; Molecular Sequence Data ; Phosphatidylinositol Phosphates/*metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Sorting Nexins/metabolism ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Displaced vertices as probes of sterile neutrino mixing at the LHC (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-08-09
    Description: Author(s): Giovanna Cottin, Juan Carlos Helo, and Martin Hirsch We investigate the reach at the LHC to probe light sterile neutrinos with displaced vertices. We focus on sterile neutrinos N with masses m N ∼ ( 5 – 30 )    GeV that are produced in rare decays of the standard model gauge bosons and decay inside the inner trackers of the LHC detectors. With a strategy that ... [Phys. Rev. D 98, 035012] Published Wed Aug 08, 2018
    Keywords: Beyond the standard model
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Predictive codes for forthcoming perception in the frontal cortex (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-11-25
    Description: Incoming sensory information is often ambiguous, and the brain has to make decisions during perception. "Predictive coding" proposes that the brain resolves perceptual ambiguity by anticipating the forthcoming sensory environment, generating a template against which to match observed sensory evidence. We observed a neural representation of predicted perception in the medial frontal cortex, while human subjects decided whether visual objects were faces or not. Moreover, perceptual decisions about faces were associated with an increase in top-down connectivity from the frontal cortex to face-sensitive visual areas, consistent with the matching of predicted and observed evidence for the presence of faces.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Summerfield, Christopher -- Egner, Tobias -- Greene, Matthew -- Koechlin, Etienne -- Mangels, Jennifer -- Hirsch, Joy -- R21066129/PHS HHS/ -- New York, N.Y. -- Science. 2006 Nov 24;314(5803):1311-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027, USA. summerfd@paradox.columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17124325" target="_blank"〉PubMed〈/a〉
    Keywords: Amygdala/physiology ; Brain Mapping ; Discrimination (Psychology) ; Face ; Female ; *Form Perception ; Frontal Lobe/*physiology ; Humans ; Magnetic Resonance Imaging ; Male ; *Mental Processes ; Models, Neurological ; Nerve Net/physiology ; Neurons/physiology ; Occipital Lobe/physiology ; Parietal Lobe/physiology ; Temporal Lobe/physiology ; Visual Cortex/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...