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  • Polymer and Materials Science  (3)
  • Basic fibroblast growth factor (bFGF)  (1)
  • 1990-1994  (4)
  • 1
    Electronic Resource
    Electronic Resource
    In vivo effects of vascular endothelial growth factor on the chicken chorioallantoic membrane (1993)
    Springer
    Cell & tissue research 274 (1993), S. 163-172 
    Details
    ISSN: 1432-0878
    Keywords: Chorioallantoic membrane ; Angiogenesis ; Vascular endothelial growth factor (VEGF) ; Basic fibroblast growth factor (bFGF) ; Heparin ; Domestic fowl (White Leghorn)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of vascular endothelial growth factor (VEGF165) on the chorioallantoic membrane (CAM) of 13-day-old chick embryos was studied. The factor was applied in doses of 0.5–4 μg for a period of up to 4 days. Macroscopical, histological and immunohistological studies were carried out. The localization of the factor was examined with an anti-VEGF antibody. The mitogenicity of VEGF165 and basic fibroblast growth factor (bFGF) were studied by means of the BrdU-anti-BrdU method. Furthermore, the effect of heparin alone and in combination with VEGF165 was investigated. VEGF165 specifically induces angiogenesis in doses of 0.5 μg and more. A brush-like formation of blood vessels can be seen in the region of the precapillary vessels. Angiogenesis also takes place in the region of the capillaries and the venules. Histologically we found indications of sprouting as well as of intussusceptive capillary growth. The presence of the factor in the application area could be demonstrated with the anti-VEGF antibody for a period of 3 days. The factor is located in the chorionic epithelium and the intraepithelial capillaries. The BrdU-studies show that VEGF165 induces strong endothelial cell proliferation, whereas bFGF elicits fibrocyte proliferation and minor endothelial cell proliferation. Heparin induces squamous metaplasia of the chorionic and allantoic epithelium in combination with an aggregation of fibrocytes. We could not detect any enhancement of VEGF165 by heparin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327997
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  • 2
    Electronic Resource
    Electronic Resource
    Integrierter Umweltschutz - Strategie zur Abfallverminderung und -vermeidungPoster auf dem Jahrestreffen der Verfahrens-Ingenieure, 25. bis 27. Sept. 1991 in Köln. (1992)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 64 (1992), S. 431-432 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330640507
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  • 3
    Electronic Resource
    Electronic Resource
    Produktintegrierter Umweltschutz in der chemischen Industrie - Chancen und GrenzenVortrag auf der Dechema-Jahrestagung, 3. bis 5. Juni 1992 in Karlsruhe. (1992)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 64 (1992), S. 889-898 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Bei der Herstellung von Chemieprodukten fallen im Produktionsprozeß häufig Stoffe an, die vom Produzenten nicht angestrebt werden. Sie werden als Rückstände oder Reststoffe bezeichnet. Die Minimierung dieser Stoffe ist Bestandteil des unternehmerischen Umweltschutzes. Am Beispiel der chemischen Industrie wird gezeigt, wie diese ökologische Zielsetzung mit dem Konzept des produktionsintegrierten Umweltschutzes erreicht wird, welche technischen Maßnahmen dazu durchgeführt werden, zu welchem Ergebnis diese führen und welche Grenzen sich hierbei ergeben. Die damit verbundene Kostensituation wird ebenfalls dargestellt.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330641003
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  • 4
    Electronic Resource
    Electronic Resource
    A comparative evaluation of the biostability of a poly (ether urethane) in the intraocular, intramuscular, and subcutaneous environments (1992)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 26 (1992), S. 607-629 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A transparent poly (ether urethane) (PEU) was considered for use as a foldable intraocular lens material. The PEU was found to possess excellent mechanical, optical, and surface characteristics for this application. In uitro hydrolytic and ultraviolet aging studies suggested the PEU to be tolerant to conditions simulating 3-10 years of normal intraocular exposure. Different behavior was obtained, however, from intraocular and subcutaneous implantation of the PEU. After 6 months of intraocular exposure in the feline model, prototype PEU lenses had lost most or all of their optical resolving power. SEM analysis demonstrated scattered pitting and cracking on the lens surfaces. Degradation was found to be more extreme after as little as 30 days of subcutaneous exposure in rabbits. Severe pitting over the entire surface of implanted flat PEU specimens was observed by SEM. Macroscopic examination showed the samples to be frosty in appearance. It was postulated that the subcutaneous implant environment provides an accelerated in uivo model for materials intended for intraocular use. A minimum acceleration of 6-10X was estimated on a preliminary basis. The PEU studied here was found to be unsuitable for use as a foldable intraocular lens material.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820260505
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