Publication Date:
1991-07-19
Description:
Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neural cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harouse, J M -- Bhat, S -- Spitalnik, S L -- Laughlin, M -- Stefano, K -- Silberberg, D H -- Gonzalez-Scarano, F -- CA-45690/CA/NCI NIH HHS/ -- NS-11037/NS/NINDS NIH HHS/ -- NS-27405/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1991 Jul 19;253(5017):320-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1857969" target="_blank"〉PubMed〈/a〉
Keywords:
*Antibodies
;
Antigens, CD4/physiology
;
Base Sequence
;
Cell Line
;
Galactosylceramides/*immunology
;
Gene Products, gag/genetics
;
Glioma
;
HIV Envelope Protein gp120/immunology
;
HIV-1/genetics/immunology/*physiology
;
Humans
;
Molecular Sequence Data
;
Polymerase Chain Reaction
;
Protein Binding
;
Recombinant Proteins/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
