Publication Date:
1989-11-17
Description:
The BAS1 and BAS2 proteins are both required for activation of GCN4-independent (basal) HIS4 transcription in yeast. BAS1 has an NH2-terminal region similar to those of the myb proto-oncogene family. BAS1 and BAS2, which contains a homeo box, bound to adjacent sites on the HIS4 promoter. The joint requirement of BAS1 and BAS2 for activation is probably not due to cooperative binding or the transcriptional control of one of the genes by the other. Although BAS1 and BAS2 were both required for activation of HIS4 transcription, BAS1 was not required for BAS2-dependent expression of the secreted acid phosphatases. The transcriptional activators of HIS4 have DNA binding domains that are conserved in evolution (BAS1 = Myb, BAS2 = homeo box, GCN4 = Jun). Their interactions, therefore, may be relevant to the control of gene expression in more complex systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tice-Baldwin, K -- Fink, G R -- Arndt, K T -- GM35010/GM/NIGMS NIH HHS/ -- GM39892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1989 Nov 17;246(4932):931-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, NY 11724.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2683089" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Fungal Proteins/*genetics
;
*Gene Expression Regulation
;
*Genes, Fungal
;
Molecular Sequence Data
;
Proto-Oncogene Proteins/*genetics
;
Proto-Oncogene Proteins c-myb
;
Saccharomyces cerevisiae/*genetics
;
*Saccharomyces cerevisiae Proteins
;
Sequence Homology, Nucleic Acid
;
*Trans-Activators
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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