Publication Date:
1998-07-24
Description:
Avirulent strains of Salmonella typhimurium are being considered as antigen delivery vectors. During its intracellular stage in the host, S. typhimurium resides within a membrane-bound compartment and is not an efficient inducer of class I-restricted immune responses. Viral epitopes were successfully delivered to the host-cell cytosol by using the type III protein secretion system of S. typhimurium. This resulted in class I-restricted immune responses that protected vaccinated animals against lethal infection. This approach may allow the efficient use of S. typhimurium as an antigen delivery system to control infections by pathogens that require this type of immune response for protection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russmann, H -- Shams, H -- Poblete, F -- Fu, Y -- Galan, J E -- Donis, R O -- New York, N.Y. -- Science. 1998 Jul 24;281(5376):565-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics and Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9677200" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Antigen Presentation
;
Antigens, Viral/immunology/metabolism
;
Bacterial Proteins/genetics/*metabolism
;
Cytosol/*immunology
;
Endoplasmic Reticulum/immunology/metabolism
;
Epitopes/*immunology
;
Histocompatibility Antigens Class I/immunology
;
Hybridomas
;
Lymphocytic Choriomeningitis/prevention & control
;
Lymphocytic choriomeningitis virus/immunology
;
Mice
;
Mice, Inbred C57BL
;
Nucleoproteins/immunology/metabolism
;
Peptide Fragments/immunology/metabolism
;
Protein Tyrosine Phosphatases/genetics/*metabolism
;
Recombinant Fusion Proteins/immunology/metabolism
;
*Salmonella typhimurium/metabolism/pathogenicity
;
T-Lymphocytes/immunology
;
T-Lymphocytes, Cytotoxic/immunology
;
Tumor Cells, Cultured
;
Vaccines, Synthetic/*administration & dosage/immunology
;
Viral Core Proteins/immunology/metabolism
;
Viral Vaccines/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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