Publication Date:
2003-12-06
Description:
Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Journet, Laure -- Agrain, Celine -- Broz, Petr -- Cornelis, Guy R -- New York, N.Y. -- Science. 2003 Dec 5;302(5651):1757-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biozentrum, Universitat Basel, 4056 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14657497" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Bacterial Proteins/analysis/*chemistry/genetics/*physiology
;
Flagella/chemistry
;
Genes, Bacterial
;
Genetic Complementation Test
;
Microscopy, Electron
;
Mutation
;
Sequence Deletion
;
Yersinia enterocolitica/*chemistry/*ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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