Publication Date:
1996-08-09
Description:
Cross-linking of the antigen receptor on lymphocytes by antigens or antibodies to the receptor results in activation of enzymes of the protein kinase C (PKC) family. Mice homozygous for a targeted disruption of the gene encoding the PKC-betaI and PKC-betaII isoforms develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B cells, which is similar to X-linked immunodeficiency in mice. Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leitges, M -- Schmedt, C -- Guinamard, R -- Davoust, J -- Schaal, S -- Stabel, S -- Tarakhovsky, A -- New York, N.Y. -- Science. 1996 Aug 9;273(5276):788-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Delbruck-Laboratorium in der Max-Planck-Gesellschaft, Carl-von-Linne-Weg 10, D-50829 Koln, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8670417" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/*immunology
;
Gene Targeting
;
Genetic Linkage
;
Immunoglobulin G/blood
;
Immunoglobulin M/blood/immunology
;
Immunoglobulins/*blood
;
Immunologic Deficiency Syndromes/enzymology/*immunology
;
Lymphocyte Activation
;
Lymphocyte Count
;
Mice
;
Protein Kinase C/deficiency/genetics/*physiology
;
Protein Kinase C beta
;
Protein-Tyrosine Kinases/genetics/metabolism
;
Receptors, Antigen, B-Cell/immunology
;
Signal Transduction
;
T-Lymphocytes/immunology
;
X Chromosome
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
