ISSN:
1432-0878
Keywords:
Capsaicin
;
Horseradish peroxydase (HRP)
;
Nerve growth factor (NGF)
;
Dorsal root ganglion
;
Neurones
;
Axoplasmic transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Capsaicin injected into the scrotal skin of rats was observed to induce a decrease in the amount of horseradish peroxidase (HRP) transported in the pudendal nerve to the sixth lumbar dorsal root ganglion on the pretreated side. This was seen as a decrease in the number of HRP-labelled neurones compared to the control side. A morphometric study confirmed that the effect of capsaicin was exerted predominantly on the small neurones. Injection of nerve growth factor (NGF) into the pudendal nerve prevented the deleterious effects of capsaicin, thereby suggesting a possible site of action and mechanism for the effect of capsaicin on peripheral nerves.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00216346
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