Publication Date:
2013-06-08
Description:
Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors (TFs) expressed by progenitors. Mechanisms that determine higher-order visual areas (V(HO)) and distinguish them from V1 are unknown. We demonstrated a requirement for thalamocortical axon (TCA) input by genetically deleting geniculocortical TCAs and showed that they drive differentiation of patterned gene expression that distinguishes V1 and V(HO). Our findings suggest a multistage process for area patterning: TFs expressed by progenitors specify an occipital visual cortical field that differentiates into V1 and V(HO); this latter phase requires geniculocortical TCA input to the nascent V1 that determines genetic distinctions between V1 and V(HO) for all layers and ultimately determines their area-specific functional properties.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851411/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851411/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou, Shen-Ju -- Babot, Zoila -- Leingartner, Axel -- Studer, Michele -- Nakagawa, Yasushi -- O'Leary, Dennis D M -- MH086147/MH/NIMH NIH HHS/ -- R01 MH086147/MH/NIMH NIH HHS/ -- R01 NS031558/NS/NINDS NIH HHS/ -- R01 NS31558/NS/NINDS NIH HHS/ -- R37 NS031558/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 7;340(6137):1239-42. doi: 10.1126/science.1232806.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23744949" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/*physiology
;
Gene Deletion
;
Gene Expression Regulation
;
Genetic Markers
;
Mice
;
Mice, Knockout
;
Neocortex/*physiology
;
Neural Stem Cells/metabolism
;
Thalamus/*physiology
;
Transcription Factors/biosynthesis
;
Visual Cortex/*physiology
;
Visual Fields/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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