Publication Date:
2014-10-11
Description:
Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of gamma-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eftekhari, Sanaz -- Shahrokhi, Amene -- Tsintsadze, Vera -- Nardou, Romain -- Brouchoud, Corinne -- Conesa, Magali -- Burnashev, Nail -- Ferrari, Diana C -- Ben-Ari, Yehezkel -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):176. doi: 10.1126/science.1256009.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Iran University of Medical Sciences, Tehran, Iran. ; Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Tehran University of Medical Sciences, Tehran, Iran. ; Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. ; Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. ; Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. yehezkel.ben-ari@inserm.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301611" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autistic Disorder/*chemically induced/*genetics
;
*Cytoprotection
;
Female
;
Oxytocin/*metabolism
;
Pregnancy
;
gamma-Aminobutyric Acid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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