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The quantification of synthetic corticosteroids using isotope dilution gas chromatography negative chemical ionization mass spectrometry (1988)

Midgley, J. M. ; Watson, D. G. ; Healey, T. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 15 (1988), S. 479-483

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ISSN: 0887-6134

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Prednisolone, dexamethasone and betamethasone were labelled with deuterium via a simple synthetic procedure and used as internal standards in the gas chromatographic/mass spectrometric analysis of the corresponding undeuterated compounds. The mass spectrometer was used in the negative chemical ionization mode, which gave fragmentation of the methoxime trimethylsilyl ether derivatives favourable for their quantification. The method was applicable to the quantification of synthetic corticosteroids contained in human aqueous humour in the 0.1-10-ng range.

Additional Material: 7 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/bms.1200150904

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Atrial granules in the dog heart after cardiac denervation (1987)

Kaczmarczyk, Gabriele ; Forssmann, Wolf-Georg ; Noble, M. I. M. ; [et al.]

Springer

Cell & tissue research 249 (1987), S. 701-705

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ISSN: 1432-0878

Keywords: Atrial natriuresis ; Cardiac denervation ; Myoendocrine cells ; Cardiodilatin (CDD) ; Atrial natriuretic polypeptide (ANP) ; Dog

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Because the increase in sodium excretion during left atrial distension in conscious dogs is abolished after chronic cardiac denervation, we have investigated whether this is a result of the disappearance of specific atrial granules. Electron microscopy and light-microscopical and ultrastructural immunohistochemistry of canine atria show that atrial granules displaying immunoreactivity for cardiac hormones of the cardiodilatin/atrial natriuretic polypeptide (CDD/ANP) family are still present in denervated left and right atria, although reduced in quantity. It is concluded that the “atrial-induced natriuresis” is not only related to the existence of specific atrial granules. The functional link between atrial-induced natriuresis provoked by atrial distension and the release of atrial polypeptide hormones remains uncertain because the denervated heart can secrete CDD although the diuretic-natriuretic effect is altered.