ISSN:
1432-0878
Keywords:
Atrial natriuretic peptide (ANP)
;
Chicken natriuretic peptide (chANP)
;
Atrial-specific granule
;
Sarcoplasmic reticulum
;
Immunohistochemistry
;
Domestic fowl (Aves, Phasianiformes)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary An immunohistochemical study using antiserum raised against synthetic chicken natriuretic polypeptide was used to investigate the distribution of this peptide in the chicken heart. Immunoreactive cells, both in the atrial and ventricular walls, were identified by electron microscopy, and electron-dense granules in the atrial and ventricular cardiocytes were revealed to be storage sites of the peptide. The electron-dense material, thought to be the peptide, was found in the sarcoplasmic reticulum, and it is suggested that a secretory pathway of the peptide through the latter to extracellular space, may be present, in addition to an exocytotic one.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00318451
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