ISSN:
0020-7608
Keywords:
Computational Chemistry and Molecular Modeling
;
Atomic, Molecular and Optical Physics
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A new theoretical approach to the cooperativity of an enzyme has been proposed. When we applied the present theory to the allosteric effect of hemoglobin, we obtained a so-called Koshland-Nemethy-Filmer formula. Our theory suggested that the sigmoid curve becomes sharper when the affinity of the first oxygen molecule of the hemoglobin is smaller.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/qua.560150404
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