ISSN:
1434-193X
Keywords:
Asymmetric synthesis
;
Enzyme catalysis
;
Lipases
;
Epoxidations
;
Chiral building blocks
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Asymmetrized tris(hydroxymethyl)methane (THYM*) is a new chiral building block easily accessible in both enantiomeric forms by a chemoenzymatic methodology. The presence of three synthetically equivalent masked hydroxymethyl groups and a high degree of latent symmetry (C3v) makes this synthon very versatile in synthetic applications. This review describes its preparation and a series of elaborations (with particular enphasis on the diastereoselective generation of additional chiral centers) leading to advanced intermediated for the preparation of biologically active compounds.
Type of Medium:
Electronic Resource
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