ISSN:
1434-193X
Schlagwort(e):
Nucleosides
;
Natural products
;
Iridoids
;
Catalpol
;
Antirrhinoside
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Two iridoid glucosides, antirrhinoside (1) and catalpol (2), were converted into selectively protected polysubstituted cyclopentylmethanols, which were subsequently used to prepare carbocyclic homo-N-nucleosides (5, 6 and 14). A purine moiety was introduced either by the Mitsunobu reaction or by substitution of a primary triflate with the tetrabutylammonium salt of 6-iodopurine. The latter method was superior with regard to both ease of purification and yield. The N-9 vs. N-7 regioselectivity of the salts of different 6-substituted purine derivatives was briefly investigated.
Materialart:
Digitale Medien
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