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HRGC assay of antihistaminic drugs in plasma samples using a nitrogen-phosphorus detector (1988)

Giachetti, C. ; Poletti, P. ; Zanolo, G.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 11 (1988), S. 525-527

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ISSN: 0935-6304

Keywords: Antihistaminic drugs ; Plasma samples ; Nitrogen-phosphorus detector ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Thirteen antihistaminic drugs are separated on a CP-Sil 5 capillary column and are evaluated by a NP detector after extraction of spiked plasma samples, alkalinized, in a solvent mixture of chloroform, dichloromethane, and methanol. Intra- and inter-assay analyses showed high reliability, therefore this method can be usefully applied in experimental or clinical pharmacokinetic investigations.

Additional Material: 1 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jhrc.1240110706

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